Association study of polymorphisms in the ABO gene with ischemic stroke in the Chinese population

BMC Neurology

Table 2 Association between SNPs and ischemic stroke using the additive, genotype, dominant, and the recessive models

SNP	Model	Allele or geno	case	control	Unadjusted OR (95 % CI)	Unadjusted p-value	Adjusted OR (95 % CI)	Adjusted p-value
rs579459	Additive	C/T	363/1455	334/1576	1.18 (1.00-1.39)	0.05	1.18 (0.97-1.43)	0.10
	Dominant	CC + CT/TT	326/583	300/655	1.22 (1.00-1.48)	0.04	1.20 (0.95-1.52)	0.12
	Recessive	CC/CT + TT	37/872	34/921	1.15 (0.71-1.85)	0.57	1.31 (0.74-2.31)	0.36
rs651007	Additive	T/C	349/1421	337/1575	1.15 (0.97-1.36)	0.10	1.15 (0.94-1.40)	0.17
	Dominant	TT + CT/CC	314/571	304/652	1.18 (0.97-1.43)	0.09	1.16 (0.92-1.46)	0.22
	Recessive	TT/CT + CC	35/850	33/923	1.15 (0.71-1.87)	0.57	1.35 (0.76-2.40)	0.31
rs529565	Additive	C/T	679/1087	709/1201	1.06 (0.93-1.21)	0.41	1.06 (0.90-1.24)	0.48
	Dominant	CC + CT/TT	540/343	565/390	1.09 (0.90-1.31)	0.38	1.08 (0.86-1.35)	0.52
	Recessive	CC/CT + TT	139/744	144/811	1.05 (0.82-1.36)	0.69	1.08 (0.79-1.47)	0.62

All SNPs were analyzed under additive, genotype, dominant (Dom) and recessive (Rec) models; OR: odds ratio; CI: confidence interval; unadjusted P-value from t-test; adjusted P-value using logistic regression analysis with age, gender, hypertension, diabetes, and dyslipidemia as covariates. Significant P values (p < 0.05) are in bold and p* < 0.017 (Bonferroni multiple correction threshold)

ISSN: 1471-2377