Table 4 Major and minor birth defects with possible temporal relationshipa to exposure
Major birth defects | Minor birth defects | Gestational age at last natalizumab dose | Maternal concomitant medications |
|---|---|---|---|
Absent right femur | NA | 4 weeks | Azelastine nasal, prenatal vitamins, zolpidem |
Anomaly of nose, cystic dysplasia of kidney, holoprosencephaly | Sandal toe gap, small anterior fontanelle | 3 weeks | Methylphenidate, prenatal vitamins |
Atrial shunt | NA | 1 week | Heparin sodium, prenatal vitamins |
Chordee with hypospadias | NA | 26 days | Fluvoxamine, hydrocodone/acetaminophen, lamotrigine, meperidine/promethazine, ondansetron hydrochloride, prenatal vitamins |
Colpocephaly, hydrocephalus, partial agenesis of corpus callosum | NA | 4 days | Methylprednisolone sodium succinate, sertraline hydrochloride |
Hydronephrosis | NA | 5 weeks | Levothyroxine, metformin, sertraline hydrochloride |
Penile concealment | NA | 3 weeks | Prenatal vitamins |
Polydactyly | NA | 5 days | Folic acid, insulin |
Tetralogy of Fallot | NA | 0 (29 days prior to LMP) | Duloxetine, prenatal vitamins, topiramate, trazodone |
Torticollis | NA | 8 weeks | Bupropion, methylprednisolone, pantoprazole, propoxyphene/ acetaminophen, topiramate |
Tricuspid valve atresia | NA | 3 weeks | NR |
Ventricular septal defect | NA | 1 day | NR |
NA | Congenital hypothyroidism | 4.5 weeks | Nitrofurantoin, prenatal vitamins, Rh0(D) immune globulin, venlafaxine hydrochloride |
NA | Irregular tragus, umbilical hernia | 11 weeks | Prenatal vitamins |
NA | Mongolian spot | 3 weeks | Escitalopram, hydrocodone, levothyroxine, modafinil, prenatal vitamins |
NA | Sacral dimple, umbilical hernia | 5 weeks | Prenatal vitamins, valacyclovir |
NA | Subcutaneous cyst | 3 weeks | Prenatal vitamins |
NA | Tight frenulum | 3 days | Prenatal vitamins, tizanidine |