From: Assessment of a multiple biomarker panel for diagnosis of amyotrophic lateral sclerosis
Subgroup | pNfH (ng/L) | P value | CHIT (ng/L) | P value | cystatin C (ng/L) | P value |
---|---|---|---|---|---|---|
Site of onset | ||||||
Spinal | 4676 (238–19002) | 0.43 | 4457 (572–7945) | 0.08 | 10330 (62–111466) | 0.35 |
Bulbar | 3022 (552–5265) | 2886 (91–7945) | 3065 (119–1113) | |||
Progression rate | ||||||
>0.91/month | 5969 (996–19002) | 0.001 | 3927 (572–7945) | 0.85 | 6566 (62–105031) | 0.80 |
≤0.91/month | 1969 (238–5030) | 3791 (91–7945) | 12900 (62–111466) | |||
Worsening rate | ||||||
>0.92/month | 6171 (1309–19002) | 0.0143 | 4668 (598–7945) | 0.67 | 5188 (78–32186) | 0.83 |
≤0.92/month | 2670 (238–13223) | 4243 (572–7945) | 15610 (62–111466) |