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Table 2 Comparison of levels of pNfH, CHIT, and cystatin C in cerebrospinal fluid between subgroups of patients with sporadic ALS

From: Assessment of a multiple biomarker panel for diagnosis of amyotrophic lateral sclerosis

Subgroup

pNfH (ng/L)

P value

CHIT (ng/L)

P value

cystatin C (ng/L)

P value

Site of onset

 Spinal

4676 (238–19002)

0.43

4457 (572–7945)

0.08

10330 (62–111466)

0.35

 Bulbar

3022 (552–5265)

2886 (91–7945)

3065 (119–1113)

Progression rate

 >0.91/month

5969 (996–19002)

0.001

3927 (572–7945)

0.85

6566 (62–105031)

0.80

 ≤0.91/month

1969 (238–5030)

3791 (91–7945)

12900 (62–111466)

Worsening rate

 >0.92/month

6171 (1309–19002)

0.0143

4668 (598–7945)

0.67

5188 (78–32186)

0.83

 ≤0.92/month

2670 (238–13223)

4243 (572–7945)

15610 (62–111466)

  1. ALS amyotrophic lateral sclerosis, CHIT chitotriosidase, pNfH phosphorylated neurofilament heavy chain