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Table 2 Comparison of levels of pNfH, CHIT, and cystatin C in cerebrospinal fluid between subgroups of patients with sporadic ALS

From: Assessment of a multiple biomarker panel for diagnosis of amyotrophic lateral sclerosis

Subgroup pNfH (ng/L) P value CHIT (ng/L) P value cystatin C (ng/L) P value
Site of onset
 Spinal 4676 (238–19002) 0.43 4457 (572–7945) 0.08 10330 (62–111466) 0.35
 Bulbar 3022 (552–5265) 2886 (91–7945) 3065 (119–1113)
Progression rate
 >0.91/month 5969 (996–19002) 0.001 3927 (572–7945) 0.85 6566 (62–105031) 0.80
 ≤0.91/month 1969 (238–5030) 3791 (91–7945) 12900 (62–111466)
Worsening rate
 >0.92/month 6171 (1309–19002) 0.0143 4668 (598–7945) 0.67 5188 (78–32186) 0.83
 ≤0.92/month 2670 (238–13223) 4243 (572–7945) 15610 (62–111466)
  1. ALS amyotrophic lateral sclerosis, CHIT chitotriosidase, pNfH phosphorylated neurofilament heavy chain