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Table 2 Principal clinical features of Fahr’s disease

From: Bilateral strio-pallido-dentate calcinosis (Fahr’s disease): report of seven cases and revision of literature

  Fahr’s disease
  Early onset Late onset
Cognitive impairment/dementia A cortical dementia may develop in advanced stages Usually starts with a subcortical dementia
Psychotic disorders Organic psychosis (basal ganglia calcification); delusion has syndromic pervasiveness behavioral, is moderately structured and organized, has low emotional participation, varied content. Abnormalities of perception are rare. Organic psychosis (dementia): delusion is poorly structured and organized, override the contents of jealousy, poisoning, and persecution. Abnormalities of perception are frequent.
Mood disorders May be associated to psychotic symptoms. Depressive disorders are prevalent towards maniacal ones. Always associated with cognitive impairment, may precede symptoms as prodromes. Prevailing depression, irritability, hyper-emotionality, apathy
Anxiety disorders Possible association between Fahr’s disease and obsessive-compulsive disorder. Possible association between Fahr’s disease and obsessive-compulsive disorder. They can also be associated to cognitive impairment
Other neuro psychiatric/cognitive disorders Possible attention’s disorders. Progressive alteration of cognitive functions (attention, language, memory, constructive abilities, etc.)
Extrapyramidal movement disorders In advanced stages of the disease. May be present since the onset.
Response to therapy Poor sensibility to neuroleptic treatment; high susceptibility to side effects. Poor response to any type of symptomatic therapy. Frequent side effects.