Skip to main content

Advertisement

Table 3 Association between the gut microbiota’s phylum-level abundance and peripheral blood immune markers

From: Associations between the gut microbiota and host immune markers in pediatric multiple sclerosis and controls

  1. aimmune markers were available for all 24 children, except as follows:: for Th17 and Th1 (n = 21 children; n = 9 controls, n = 12 cases [6 DMD exposed, 6 DMD naïve]); for Tr1 and Th2 (n = 20 children; n = 8 controls, n = 12 cases [6 DMD exposed, 6 DMD naïve])
  2. No correction for multiple testing. Seven immune markers were assessed for correlation with three diversity metrics and 13 phyla, resulting in 7 × 3 = 21 tests (Table 2) and 7 × 13 = 91 tests (Table 3) respectively. Chance significance would be expected for 1 in 20 tests, i.e. approximately 1 test (diversity) and 4–5 tests (phylum-level)
  3. Remaining blood immune markers (total T cells) and phyla (Verrucomicrobia, Proteobacteria, Euryarchaeota, Tenericutes, Cyanobacteria, Deferribacteres, Synergistetes, TM7 and Lentisphaerae) are not shown here due to few significant findings and/or low abundances for the phyla. Except as follows
  4. For all children: Lentisphaerae and Tregs (r = 0.427, p = 0.037); TM7 and total T cells (r = −0.590, p = 0.002)
  5. Cases: Lentisphaerae and Tr1 (r = 0.703, p = 0.011); TM7 and total T cells (r = −0.628, p = 0.012)