Table 2 a) Observed group mean values (± SD) for α-synuclein at inclusion (baseline), and after one and two years, and b) predicted mean value (95 % CI) at baseline, together with estimated mean change (95 % CI) from baseline valuesa
α-synuclein (pg/mL) | ||||||
|---|---|---|---|---|---|---|
AD-AD | MCI-AD | MCI-MCI | CTR | p-valueb | p-valuec | |
a) | ||||||
Baseline | 494.4 ± 275.0 | 671.8 ± 383.1 | 568.6 ± 390.5 | 514.4 ± 263.1 | 0.26 | |
1 year | 466.0 ± 324.8 | 650.9 ± 458.4 | 559.5 ± 339.6 | na | ||
2 years | 439.4 ± 285.5 | 587.4 ± 386.5 | 565.7 ± 393.3 | na | ||
b) | ||||||
Baseline | 477.3 (333.3,621.4) | 661.7 (514.3,809.0) | 568.6 (415.4,721.2) | 0.22 | ||
Mean change | 0.93 | |||||
After 1 year | −11.3 (−76.9, 54.3) | −16.7 (−85.8, 52.3) | −9.0 (−77.8, 59.7) | 0.23 | ||
After 2 years | −9.0 (−77.7, 59.7) | −42.0 (−112.2, 28.1) | 0.02 (−69.9, 69.9) | 0.33 | ||
Linear trendd | −4.6 (−38.6, 29.4) | −21.0 (−55.7, 13.7) | −0.09 (−34.6, 34.5) | 0.67 | ||