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Table 2 GRADE evidence table for the comparison betalactam antibiotics vs. doxycycline for children with Lyme neuroborreliosis

From: Efficacy and safety of pharmacological treatments for Lyme neuroborreliosis in children: a systematic review

Quality assessment № of patients Effect Quality
№ of studies Study design Risk of bias Inconsistency Indirectness Imprecision Betalactam antibiotics Doxycycline Relative (95 % CI)
Neurological symptoms at last reported time point
3 observational studies very seriousa not serious seriousb seriousc 15/195 (7.7 %) 3/25 (12.0 %) not pooled VERY LOW
  1. abaseline confounding, selected patients, lack of blinding, interventions insufficiently described
  2. bheterogeneous interventions, interventions not clearly described
  3. csmall sample size, optimal information size not met