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Table 3 GRADE evidence table for the comparison penicillin vs. ceftriaxone for children with Lyme neuroborreliosis

From: Efficacy and safety of pharmacological treatments for Lyme neuroborreliosis in children: a systematic review

Quality assessment № of patients Effect Quality
№ of studies Study design Risk of bias Inconsistency Indirectness Imprecision Penicillin Ceftriaxone Relative (95 % CI)
Neurological symptoms at last reported time point
1 randomised trials seriousa not serious not serious very seriousb 0/11 (0.0 %) 0/12 (0.0 %) not estimable VERY LOW
Neurological symptoms at last reported time point
2 observational studies very seriousc not serious seriousd seriouse 2/55 (3.6 %) 4/28 (14.3 %) not pooled VERY LOW
  1. ano blinding, randomisation and allocation concealment not stated appropriately, selective outcomes reporting cannot be excluded
  2. bvery small sample size, optimal information size not met
  3. cbaseline confounding, selected patients, lack of blinding, interventions insufficiently described
  4. dheterogeneous interventions, interventions not clearly described
  5. esmall sample size, optimal information size not met