|
Quality assessment
|
№ of patients
|
Effect
|
Quality
|
|---|
|
№ of studies
|
Study design
|
Risk of bias
|
Inconsistency
|
Indirectness
|
Imprecision
|
Penicillin
|
Ceftriaxone
|
Relative (95 % CI)
|
|---|
|
Neurological symptoms at last reported time point
|
|
1
|
randomised trials
|
seriousa
|
not serious
|
not serious
|
very seriousb
|
0/11 (0.0 %)
|
0/12 (0.0 %)
|
not estimable
| ⨁◯◯◯ VERY LOW |
|
Neurological symptoms at last reported time point
|
|
2
|
observational studies
|
very seriousc
|
not serious
|
seriousd
|
seriouse
|
2/55 (3.6 %)
|
4/28 (14.3 %)
|
not pooled
| ⨁◯◯◯ VERY LOW |
- ano blinding, randomisation and allocation concealment not stated appropriately, selective outcomes reporting cannot be excluded
- bvery small sample size, optimal information size not met
- cbaseline confounding, selected patients, lack of blinding, interventions insufficiently described
- dheterogeneous interventions, interventions not clearly described
- esmall sample size, optimal information size not met
