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Table 4 GRADE evidence table for the comparison combination of antibiotics vs. single drugs for children with Lyme neuroborreliosis

From: Efficacy and safety of pharmacological treatments for Lyme neuroborreliosis in children: a systematic review

Quality assessment

№ of patients

Effect

Quality

№ of studies

Study design

Risk of bias

Inconsistency

Indirectness

Imprecision

Combination of antibiotics

Single drugs

Relative (95 % CI)

Neurological symptoms at last reported time point

1

observational studies

very seriousa

not serious

seriousb

seriousc

1/7 (14.3 %)

2/2 (100.0 %)

RR 4.44 (0.96 to 20.50)

VERY LOW

  1. acritical risk of bias according to ARCOBAT NRSI due to baseline confounding, selected patients, lack of blinding, interventions insufficiently described
  2. bheterogeneous interventions applied
  3. csmall sample size, optimal information size not met