Clinical predictors of seizure recurrence after the first post-ischemic stroke seizure

BMC Neurology

Table 5 Validity tests for post-ischemic stroke seizure recurrence risk score models

	Version	Items^a	AUC	95 % CI	Criteria	Sensitivity	Specificity	+ LR	- LR
Early	Score 1-1	Y, M, A, B, C, H, D, E, F, P	0.653	0.502–0.784	6	58.8 %	67.7 %	1.82	0.61
PSSi	Score 1-2	Y, M, A, B, C, H, mRS, E, F, P	0.650	0499–0.782	9	52.9 %	80.7 %	2.74	0.58
	Score 2-1	B, C, H, D, E, F, P	0.621	0.470–0.757	5	64.7 %	71.0 %	2.23	0.50
	Score 2-2	B, C, H, mRS, E, F, P	0.622	0.471–0.758	8	52.9 %	80.7 %	2.74	0.58
	Score 3-1	M, A, C, D, P	0.735	0.588–0.852	3	70.6 %	71.0 %	2.43	0.41
	Score 3-2	M, A, C, mRS, P	0.676	0.525–0.803	6	47.1 %	80.7 %	2.43	0.66
	MESS	mRS ≥ 1, abnormal EEG	0.509	0.361–0.657	1	70.6 %	35.5 %	1.09	0.83
	PoSERS	Supratentorial (X 2), C, H, mRS ≥ 3	0.576	0.425–0.717	3	58.8 %	58.1 %	1.40	0.71
Late	Score 1-1	Y, M, A, B, C, H, D, E, F, P	0.566	0.447–0.679	7	46.0 %	61.5 %	1.19	0.88
PSSi	Score 1-2	Y, M, A, B, C, H, mRS, E, F, P	0.558	0.439–0.671	9	40.5 %	69.2 %	1.32	0.86
	Score 2-1	B, C, H, D, E, F, P	0.534	0.416–0.649	5	43.2 %	59.0 %	1.05	0.96
	Score 2-2	B, C, H, mRS, E, F, P	0.526	0.408–0.642	7	54.1 %	59.0 %	1.32	0.78
	Score 4	Y, M, B, P	0.734	0.620–0.829	3	62.2 %	81.1 %	3.46	0.46
	MESS	mRS ≥ 1, abnormal EEG	0.594	0.475–0.705	1	32.4 %	87.2 %	2.53	0.78
	PoSERS	Supratentorial (X 2), C, H, mRS ≥ 3	0.532	0.414–0.647	4	21.6 %	89.7 %	2.11	0.87

AUC area under the curve, CI confidence interval, +LR positive likely-hood ratio, -LR negative likely-hood ratio, mRS modified Rankin Score, MESS MRC Multicenter trial for Early Epilepsy and Single Seizure, PoSERS Post-Stroke Epilepsy Risk Scale, EEG electroencephalography
^a Y, younger age - below 65 years old (1); M, male (1); A, atrial fibrillation (1); B, bigger lesion size - small (0), moderate (1), large (2); C, cortical involvement (1); H, hemorrhagic transformation (1); D, functional disability - mild (0), moderate (1), severe (2); E, status epilepticus (1); F, relevant focal EEG finding (1); P, partial seizure (1)

ISSN: 1471-2377