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Table 2 Correlation between age at onset and other characteristics of tremor (n = 42 patients)

From: A step toward essential tremor gene discovery: identification of extreme phenotype and screening of HTRA2 and ANO3

 

AAO ≤ 30 years (early onset ET)

AAO ≥ 55 years (late onset ET)

p

(n = 14)

(n = 28)

Family history of essential tremor (n = 42)

93% (n = 13)

36% (n = 10)

0.0007

Benefit of alcohol (n = 33)

54% (n = 6)

9% (n = 2)

0.008

Duration of tremor, years (SD) (n = 42)

29 (+/−16)

6.5 (+/−6)

<0.0001

TETRAS score/duration of tremor (SD) (n = 42)

0.4 (+/−0.2)

2.3 (+/−2.3)

<0.0001

Head tremor (n = 42)

21% (n = 3)

29% (n = 8)

1.00

Lower limbs tremor (n = 42)

21% (n = 3)

0% (n = 0)

0.03

Rest tremor (n = 42)

21.4% (n = 3)

17.8% (n = 5)

0.85

Mean frequency, Hertz (SD) (n = 42)

7.0 (+/−2)

6.2 (+/−1)

0.23

TETRAS score (SD) (n = 42)

9.6 (+/−4)

7.8 (+/−5)

0.15

Response to beta-blockers (n = 23)

77% (n = 10)

70% (n = 7)

1.00

Response to primidone (n = 10)

80% (n = 4)

60% (n = 3)

1.00

  1. AAO age at onset, SD standard deviation, TETRAS The Essential Tremor Rating Assessment Scale