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Table 1 Eligibility criteria for the 4C Study

From: A profile of The Clinical Course of Cognition and Comorbidity in Mild Cognitive Impairment and Dementia Study (The 4C study): two complementary longitudinal, clinical cohorts in the Netherlands

Inclusion criteria The 4C–MCI cohort The 4C–Dementia cohort
 • Cognitive performance subjective cognitive complaints and/or objective cognitive impairments objective cognitive impairments
 • Fulfil the DSM-IV diagnostic criteria for dementia [12] No Yes
 • Clinical Dementia Rating (CDR) Scale [34] 0–0.5 0.5–2
 • Mini Metal State Examination (MMSE) score [35] Not specified ≥10
 • Age ≥ 55 years Not specified
Exclusion criteria (similar for both cohorts)   
 • The absence of a reliable informant (who has contact with the participant for at least once a week);
 • If the participant was expected unable to have at least one follow-up based on clinical judgment of the physician responsible for the care of the patient at the memory clinic;
 • The presence of other neurological disorders that could cause cognitive impairment or affect cognitive performance, such as Parkinson’s Disease, Huntington’s Disease, Normal Pressure Hydrocephalus (NPH), Korsakov’s syndrome, and a medical history of brain tumour, encephalitis or epilepsy. However, participants suffering from other cerebrovascular or psychiatric disorders were included in the studies.