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Table 1 Eligibility criteria for the 4C Study

From: A profile of The Clinical Course of Cognition and Comorbidity in Mild Cognitive Impairment and Dementia Study (The 4C study): two complementary longitudinal, clinical cohorts in the Netherlands

Inclusion criteria

The 4C–MCI cohort

The 4C–Dementia cohort

 • Cognitive performance

subjective cognitive complaints and/or objective cognitive impairments

objective cognitive impairments

 • Fulfil the DSM-IV diagnostic criteria for dementia [12]

No

Yes

 • Clinical Dementia Rating (CDR) Scale [34]

0–0.5

0.5–2

 • Mini Metal State Examination (MMSE) score [35]

Not specified

≥10

 • Age

≥ 55 years

Not specified

Exclusion criteria (similar for both cohorts)

  

 • The absence of a reliable informant (who has contact with the participant for at least once a week);

 • If the participant was expected unable to have at least one follow-up based on clinical judgment of the physician responsible for the care of the patient at the memory clinic;

 • The presence of other neurological disorders that could cause cognitive impairment or affect cognitive performance, such as Parkinson’s Disease, Huntington’s Disease, Normal Pressure Hydrocephalus (NPH), Korsakov’s syndrome, and a medical history of brain tumour, encephalitis or epilepsy. However, participants suffering from other cerebrovascular or psychiatric disorders were included in the studies.