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Table 3 Pain medication during the study (safety analysis set)

From: Capsaicin 8% patch repeat treatment plus standard of care (SOC) versus SOC alone in painful diabetic peripheral neuropathy: a randomised, 52-week, open-label, safety study

Pain medicationa

Capsaicin 8% patch

(30 min) + SOC (n = 156)

Capsaicin 8% patch

(60 min) + SOC (n = 157)

SOC (n = 155)

Overall, n (%)

98 (62.8)

105 (66.9)

107 (69.0)

Most commonly used category (>10 % patients in either group), n (%)

 Analgesicsb

79 (50.6)

84 (53.5)

81 (52.3)

 Antiepileptics

54 (34.6)

57 (36.3)

73 (47.1)

 Topical products for joint and muscular pain

30 (19.2)

35 (22.3)

29 (18.1)

 Anti-inflammatory/antirheumatic products

29 (18.6)

35 (22.3)

30 (19.4)

 Psycholeptics

24 (15.4)

22 (14.0)

40 (25.8)

 Stomatological preparations

18 (11.5)

22 (14.0)

18 (11.6)

 Psychoanaleptics

16 (10.3)

6 (3.8)

21 (13.5)

 Ophthalmologicalsc

15 (9.6)

20 (12.7)

16 (10.3)

Most commonly used drugs (>5% patients in any group), n (%)

 Gabapentin

26 (16.7)

26 (16.6)

35 (22.6)

 Pregabalin

24 (15.4)

22 (14.0)

39 (25.2)

 Paracetamol

23 (14.7)

36 (22.9)

6 (3.9)

 Tramadol

16 (10.3)

14 (8.9)

6 (3.9)

 Diclofenac

12 (7.7)

13 (8.3)

12 (7.7)

 Ibuprofen

11 (7.1)

15 (9.6)

14 (9.0)

 Metamizole

10 (6.4)

10 (6.4)

5 (3.2)

 Duloxetine

9 (5.8)

3 (1.9)

10 (6.5)

 Carbamazepine

7 (4.5)

14 (8.9)

10 (6.5)

 Alpha lipoic acid

3 (1.9)

1 (0.6)

8 (5.2)

  1. SOC standard of care
  2. aMedication used for pain (check box of ‘pain medication’ is YES on electronic case report form [eCRF])
  3. bAnalgesics were categorised by class: anilides, natural opium alkaloids, other analgesics and antipyretics, other opioids, pyrazolones, and salicylic acid and derivatives
  4. cOphthalmologicals (eye treatments) were categorised by anti-inflammatory agents and nonsteroids, local anaesthetics, corticosteroids (plain) and other ophthalmologicals