Serum albumin to globulin ratio is related to cognitive decline via reflection of homeostasis: a nested case-control study

Table 3 Logistic regression analysis according to CD condition

	Number		Model I		Model II		Model III
	Control	CD	OR	95% CI	OR	95% CI	OR	95% CI
BMI	117	34	1.073	0.998-1.154	1.060	0.910-1.235	1.024	0.868-1.207
SBP	117	34	0.999	0.938-1.151	0.994	0.971-1.017	0.971	0.941-1.002
DBP	117	34	1.010	0.970-1.052	0.998	0.954-1.044	0.997	0.941-1.036
Triglyceride	115	34	1.003	0.996-1.011	1.002	0.994-1.010	1.002	0.989-1.015
Total cholesterol	115	34	1.001	0.998-1.022	1.009	0.995-1.022	1.009	0.995-1.022
HDL-C	115	34	0.972	0.946-0.999	0.977	0.950-1.004	0.973	0.942-1.005
non-HDL-C	115	34	1.014	1.003-1.025	1.013	1.001-1.025	1.013	1.001-1.027
Total Protein	115	34	2.971	1.023-8.622	3.575	1.088-11.74	3.219	0.938-11.04
Albumin	115	34	2.035	0.291-14.21	1.980	0.243-16.12	1.852	0.218-15.71
A/G ratio	99	30	0.063	0.006-0.619	0.032	0.003-0.379	0.037	0.003-0.470
Creatinine	115	34	2.688	0.207-34.86	2.852	0.185-43.87	2.235	0.135-36.88
Uric acid	115	34	1.007	0.695-1.459	1.037	0.707-1.520	1.068	0.730-1.563
HbA1c	117	34	2.433	1.156-5.118	2.405	1.131-5.112	2.586	1.036-6.455
hsCRP	71	26	12.95	0.104-1617	66.97	0.303-14824	42.42	0.127-14225
C. pneumoniae seropositivity	117	34	1.297	0.580-2.899	1.437	0.619-3.336	1.593	0.664-3.82
H. pylori seropositive	117	34	3.507	1.398-8.801	4.867	1.754-13.50	4.786	1.710-13.39
Pulse wave velocity in 2006-2008	116	34	1.184	1.021-1.371	1.209	1.028-1.422	1.179	0.989-1.404
Pulse wave velocity in 2012-2014	116	34	1.158	1.015-1.322	1.145	0.989-1.327	1.125	0.963-1.313
Education	113	34	2.129	0.927-4.890
ApoE4 carrier	115	33	0.781	0.310-1.970

Model I: Adjusted for age and sex
Model II: Adjusted for age, sex, apolipoprotein E4, education, smoking and alcohol drinking habits
Model III: Adjusted for age, sex, apolipoprotein E4, education, smoking and alcohol drinking habits, hypertension, hyperlipidemia and diabetes
CD cognitive decline, OR odds ratio, CI confidence interval, A/G albumin to globulin, H. pylori Helicobacter pylori, C. pneumoniae Chlamydia pneumoniae, ApoE apolipoprotein E, BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, HDL-C high-density lipoprotein cholesterol, HbA1c hemoglobin A1c, hsCRP high sensitive C-reactive protein

ISSN: 1471-2377