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Table 1 Top 10 functional network functions affected in Parkinson’s disease versus normal skin as analysed by Ingenuity Pathway Analysis. The first number in the score column reflects the number of genes in a reference gene set and the second reflects the number of focus genes altered in our study

From: Looking beyond the brain to improve the pathogenic understanding of Parkinson’s disease: implications of whole transcriptome profiling of Patients’ skin

 

Associated Network Function

Score/

nr of genes

1

Gene expression, Protein synthesis, Dermatological diseases and conditions

46/28

2

Dermatological diseases and conditions, Immunological disease, Inflammatory disease

35/23

3

Cellular assembly and organization, Behaviour, Cell signalling

34/23

4

Cancer, Immunological disease, Cellular development

33/22

5

Connective tissue disorder, Dermatological diseases and conditions, Developmental disorder

30/21

6

Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry

28/21

7

Molecular Transport, Neurological Disease, Psychological Disorders

28/20

8

Cellular Movement, Haematological System Development and Function, Immune Cell Trafficking

21/18

9

Cellular Growth and Proliferation, Haematological System Development and Function, Tissue Development

21/16

10

Lipid Metabolism, Small Molecule Biochemistry, Vitamin and Mineral Metabolism

19/16