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Table 1 Top 10 functional network functions affected in Parkinson’s disease versus normal skin as analysed by Ingenuity Pathway Analysis. The first number in the score column reflects the number of genes in a reference gene set and the second reflects the number of focus genes altered in our study

From: Looking beyond the brain to improve the pathogenic understanding of Parkinson’s disease: implications of whole transcriptome profiling of Patients’ skin

  Associated Network Function Score/
nr of genes
1 Gene expression, Protein synthesis, Dermatological diseases and conditions 46/28
2 Dermatological diseases and conditions, Immunological disease, Inflammatory disease 35/23
3 Cellular assembly and organization, Behaviour, Cell signalling 34/23
4 Cancer, Immunological disease, Cellular development 33/22
5 Connective tissue disorder, Dermatological diseases and conditions, Developmental disorder 30/21
6 Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry 28/21
7 Molecular Transport, Neurological Disease, Psychological Disorders 28/20
8 Cellular Movement, Haematological System Development and Function, Immune Cell Trafficking 21/18
9 Cellular Growth and Proliferation, Haematological System Development and Function, Tissue Development 21/16
10 Lipid Metabolism, Small Molecule Biochemistry, Vitamin and Mineral Metabolism 19/16