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Effects of acetyl-DL-leucine on cerebellar ataxia (ALCAT trial): study protocol for a multicenter, multinational, randomized, double-blind, placebo-controlled, crossover phase III trial

  • Katharina Feil1, 2, 11Email authorView ORCID ID profile,
  • Christine Adrion3,
  • Julian Teufel1, 2,
  • Sylvia Bösch8,
  • Jens Claassen5,
  • Ilaria Giordano7,
  • Holger Hengel6,
  • Heike Jacobi7,
  • Thomas Klockgether7,
  • Thomas Klopstock1, 4, 12,
  • Wolfgang Nachbauer8,
  • Ludger Schöls6,
  • Claudia Stendel1, 4,
  • Ellen Uslar5,
  • Bart van de Warrenburg9,
  • Ingrid Berger2,
  • Ivonne Naumann2,
  • Otmar Bayer2,
  • Hans-Helge Müller10,
  • Ulrich Mansmann3 and
  • Michael Strupp1, 2
BMC NeurologyBMC series – open, inclusive and trusted201717:7

https://doi.org/10.1186/s12883-016-0786-x

Received: 17 May 2016

Accepted: 14 December 2016

Published: 10 January 2017

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Open Peer Review reports

Pre-publication versions of this article are available by contacting info@biomedcentral.com.

Original Submission
17 May 2016 Submitted Original manuscript
2 Aug 2016 Reviewed Reviewer Report - Gulin Oz
4 Sep 2016 Reviewed Reviewer Report - Louise Corben
12 Sep 2016 Reviewed Reviewer Report - Raja Mehanna
18 Oct 2016 Author responded Author comments - Katharina Feil
Resubmission - Version 2
18 Oct 2016 Submitted Manuscript version 2
21 Oct 2016 Reviewed Reviewer Report - Gulin Oz
25 Oct 2016 Reviewed Reviewer Report - Raja Mehanna
27 Oct 2016 Reviewed Reviewer Report - Louise Corben
31 Oct 2016 Author responded Author comments - Katharina Feil
Resubmission - Version 3
31 Oct 2016 Submitted Manuscript version 3
8 Nov 2016 Author responded Author comments - Katharina Feil
Resubmission - Version 4
8 Nov 2016 Submitted Manuscript version 4
Publishing
14 Dec 2016 Editorially accepted
10 Jan 2017 Article published 10.1186/s12883-016-0786-x

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article are available by contacting info@biomedcentral.com.

You can find further information about the peer review system here.

Authors’ Affiliations

(1)
Department of Neurology with Friedrich-Baur-Institute, University Hospital, Munich, Germany
(2)
German Center for Vertigo and Balance Disorders (DSGZ), University Hospital, Munich, Germany
(3)
Institute for Medical Informatics, Biometry and Epidemiology (IBE), University Hospital, Munich, Germany
(4)
German Center for Neurodegenerative Diseases (DZNE), Munich, Germany
(5)
Department of Neurology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
(6)
Department of Neurology and Hertie Institute for Clinical Brain Research, University Hospital Tübingen, Tübingen, Germany
(7)
German Center for Neurodegenerative Diseases (DZNE), Center for Clinical Research, Bonn, Germany
(8)
Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
(9)
Department of Neurology, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Centre, Nijmegen, Netherlands
(10)
Institute for Medical Biometry and Epidemiology, Philipps University Marburg, Marburg, Germany
(11)
Department of Neurology and German Center for Vertigo and Balance Disorders, University Hospital, Campus Grosshadern, Munich, Germany
(12)
Munich Cluster for Systems Neurology (SyNergy), Munich, Germany

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