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Table 4 Heart rate dynamics by subgroup within 6 h post-dose

From: Electrocardiographic assessments and cardiac events after fingolimod first dose – a comprehensive monitoring study

  Number of patients Pre-dose heart ratea (bpm) Lowest post-dose heart ratea (bpm) Maximum decline in heart ratea (bpm)
n (%) Mean (range) Mean (range) Mean (SD)
  Fingolimod, N = 3951
Overall population
 Overall population 3951 (100.0) 73.9 (45–132) 62.1 (31–101) 11.8 (8.47)
By time of lowest heart rate
 Patients with lowest heart rate at < 6 h 3455 (87.4) 73.8 (45–132) 61.9 (31–101) 11.9 (8.42)
 Patients with lowest heart rate at 6 h 496 (12.6) 74.6 (48–114) 63.5 (38–90) 11.1 (8.76)
p-valueb     0.0394
By presence of bradycardia
 Patients with bradycardia 31 (0.8) 59.5 (46–80) 41.6 (31–44) 17.9 (8.30)
 Patients without bradycardia 3920 (99.2) 74.0 (45–132) 62.2 (45–101) 11.7 (8.45)
p-valueb     0.0001
By presence of second-degree AV block
 Patients with second-degree AV block 62 (1.6) 75.0 (56–95) 62.7 (42–83) 12.2 (8.12)
 Patients without second-degree AV block 3889 (98.4) 73.8 (45–132) 62.1 (31–101) 11.8 (8.48)
p-valueb     0.691
  1. aas measured by on-site study personnel
  2. bStudents t-test