Table 2 Summary of studies included into meta-analysis
Polymorphism | Genotype Model | Ethnicity | Total No. | Male %/Female % | Mean Age (years) | Aetiology of epilepsy | Type of epilepsy | AEDs | Reference | |
|---|---|---|---|---|---|---|---|---|---|---|
ABCB1 c.3435C>T | CC vs. TT | Chinese | Cases | 331 | 56.193/43.807 | 39.1±11 a | Cryptogenic | Generalized, partial | – | Hung et al., 2005 [22] |
38.5±13.4 b | Cryptogenic, idiopathic | |||||||||
Controls | – | – | – | – | – | – | ||||
Cases | 331 | – | 40.11±11 a | Cryptogenic | Generalized, partial | CBZ, CNZ, GBP, LTG, OXC, PB, PHT, TPM, VGB, VPA | Hung et al., 2007 [23] | |||
39.5±13.4 b | Cryptogenic, idiopathic |  | ||||||||
Controls | 287 | – | 41±10.9 | – | – | – | ||||
Egyptian | Cases | 100 | 56 /44 | 35.9 ±8.42 | – | Generalized, partial | PHT a | Ebid et al., 2007 [24] | ||
Controls | 50 | 64/36 | 38.6±10.32 | – | – | – | ||||
European | Cases | 289 | 49.827/50.173 | 27.0 ±18.5 a 26.0 ±19.8 b | Various d | Generalized, partial | – | Sánchez et al., 2010 [31] | ||
Controls | – | – | – | – | – | – | ||||
Cases | 315 | – | – | – | Generalized, partial | – | Siddiqui et al., 2003 [25] | |||
Controls | 200 | – | – | – | – | – | ||||
Cases | 173 | 50.289/49.711 | 8.5±4.84 a 8.2±4.019 b | – | – | CBZ, GBP, LEV, LTG, OXC, TPM | Stasiołek et al., 2016 [26] | |||
Controls | 98 | 53.061/46.939 | 8.3±4.64 | – | – | – | ||||
Indian | Cases | 115 | 73.215/26.786 | 34.69±10.06 a 38.02±11.46 b | – | – | CBZ, PB, PHT | Taur et al., 2014 [27] | ||
Controls | – | – | – | – | – | – | ||||
Iranian | Cases | 332 | 52.711/47.289 | 28.8±11 a 27±13 b | Various d | Generalized, partial | CBZ, CNZ, LEV, LTG, OXC, PB, PHT, PRI, TPM, VPA | Sayyah et al., 2011 [28] | ||
Controls | – | – | – | – | – | – | ||||
Thai | Cases | 110 | 52.727/47.273 | 41.96 ±12.19 a 46.65±12.65 b | – | Generalized, partial | CBZ, PB, PHT, VPA | Keangpraphun et al., 2015 [29] | ||
Controls | – | – | – | – | – | – | ||||
ABCB1 c.3435C>T | TT vs. CC | Australian | Cases | 609 | – | – | – | Generalized, partial | – | Tan et al., 2004 [33] |
Controls | – | – | – | – | – | – | ||||
Chinese | Cases | 746 | – | – | Various d | – | – | Kwan et al., 2007 [34] | ||
Controls | – | – | – | – | – | – | ||||
Indian | Cases | 220 | 65.455/34.545 | 8.1±2.47 e 38.3±12.2 f | Various d | Generalized, partial | CBZ, CLB, LEV, OXC, PHT, VPA | Shaheen et al., 2013 [35] | ||
Controls | 220 | 65.455/34.545 | 10.5±4.5 e 37±10 f | – | – | – | ||||
Japanese | Cases | 210 | 56.667/43.333 | 18.0±9.6 a 16.5±9.5 b | Various d | Generalized, partial | AZA, CBZ, CLB, CNZ, DZP, ESM, Ethotoin, NTZ, PB, PHT, VPA, ZNS | Seo et al., 2006 [36] | ||
Controls | – | – | – | – | – | – | ||||