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Table 2 Summary of studies included into meta-analysis

From: Relationship between ABCB1 3435TT genotype and antiepileptic drugs resistance in Epilepsy: updated systematic review and meta-analysis

Polymorphism Genotype Model Ethnicity Total No. Male %/Female % Mean Age (years) Aetiology of epilepsy Type of epilepsy AEDs Reference
ABCB1
c.3435C>T
CC vs. TT Chinese Cases 331 56.193/43.807 39.1±11 a Cryptogenic Generalized, partial Hung et al., 2005 [22]
38.5±13.4 b Cryptogenic, idiopathic
Controls
Cases 331 40.11±11 a Cryptogenic Generalized, partial CBZ, CNZ, GBP, LTG, OXC, PB, PHT, TPM, VGB, VPA Hung et al., 2007 [23]
39.5±13.4 b Cryptogenic, idiopathic  
Controls 287 41±10.9
Egyptian Cases 100 56 /44 35.9 ±8.42 Generalized, partial PHT a Ebid et al., 2007 [24]
Controls 50 64/36 38.6±10.32
European Cases 289 49.827/50.173 27.0 ±18.5 a
26.0 ±19.8 b
Various d Generalized, partial Sánchez et al., 2010 [31]
Controls
Cases 315 Generalized, partial Siddiqui et al., 2003 [25]
Controls 200
Cases 173 50.289/49.711 8.5±4.84 a
8.2±4.019 b
CBZ, GBP, LEV, LTG,
OXC, TPM
Stasiołek et al., 2016 [26]
Controls 98 53.061/46.939 8.3±4.64
Indian Cases 115 73.215/26.786 34.69±10.06 a
38.02±11.46 b
CBZ, PB, PHT Taur et al., 2014 [27]
Controls
Iranian Cases 332 52.711/47.289 28.8±11 a
27±13 b
Various d Generalized, partial CBZ, CNZ, LEV, LTG, OXC, PB, PHT, PRI, TPM, VPA Sayyah et al., 2011 [28]
Controls
Thai Cases 110 52.727/47.273 41.96 ±12.19 a
46.65±12.65 b
Generalized, partial CBZ, PB, PHT, VPA Keangpraphun et al., 2015 [29]
Controls
ABCB1
c.3435C>T
TT vs. CC Australian Cases 609 Generalized, partial Tan et al., 2004 [33]
Controls
Chinese Cases 746 Various d Kwan et al., 2007 [34]
Controls
Indian Cases 220 65.455/34.545 8.1±2.47 e
38.3±12.2 f
Various d Generalized, partial CBZ, CLB, LEV, OXC, PHT, VPA Shaheen et al., 2013 [35]
Controls 220 65.455/34.545 10.5±4.5 e
37±10 f
Japanese Cases 210 56.667/43.333 18.0±9.6 a
16.5±9.5 b
Various d Generalized, partial AZA, CBZ, CLB, CNZ, DZP, ESM, Ethotoin, NTZ, PB, PHT, VPA, ZNS Seo et al., 2006 [36]
Controls
  1. Abbreviation: AEDs anti-epileptic drugs, ABCB1 atp-binding cassette sub-family b member 1, AZA acetazolamide, CBZ carbamazepine, CLB clobazam, CNZ clonazepam, DZP diazepam, ESM ethosuximide, GBP gabapentin, LEV levetiracetam, LTG lamotrigine, NTZ nitrozepam, OXC oxcarbazepine, PB phenobarbital, PHT phenytoin, PRI primidone, TPM topiramate, VGB vigabatrin, VPA valproate, ZNS zonisamide, − = no data, a AEDs-resistant cases, b AEDs-responsive cases, c Administration of PHT as monotherapy or polytherapy was not mentioned, d Idiopathic, cryptogenic, symptomatic, e <15 years, f >15 years