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Table 1 Clinical demographics, radiological findings, and laboratory findings for the 63 patients included in the study

From: Elevated blood viscosity is associated with cerebral small vessel disease in patients with acute ischemic stroke

 

Total (n = 63)

 

SAO

(n = 25, 39.7%)

LAA

(n = 23, 36.5%)

CE

(n = 12, 19.0%)

Cryp

(n = 3, 4.8%)

P value

Blood viscosity (mean ± sd)

 

 Diastolic blood viscosity, mP

274.7 ± 70.9

214.5 ± 75.9

252.0 ± 57.5

258.9 ± 46.5

0.037*

 Systolic blood viscosity, mP

45.2 ± 16.0

38.1 ± 12.4

40.0 ± 4.9

39.0 ± 4.7

0.273

Clinical findings

 

 Age, years (mean ± sd)

62.7 ± 12.9

67.0 ± 15.5

71.2 ± 11.6

63.3 ± 7.5

0.335

 Male, n (%)

19 (76)

13 (57)

7 (58)

2 (67)

0.513

 Hypertension, n (%)

16 (64)

16 (70)

5 (42)

3 (100)

0.207

 Diabetes, n (%)

6 (24)

7 (30)

3 (25)

0 (0)

0.716

 Hyperlipidemia, n (%)

6 (24)

3 (13)

1 (8)

0 (0)

0.484

 Atrial fibrillation, n (%)

0 (0)

0 (0)

9 (75)

0 (0)

<0.001

 Smoking, n (%)

14 (56)

8 (35)

2 (17)

0 (0)

0.053

Radiological findings, median (IQR)

 

 PVH, Fazekas scale

1 (1–2)

1 (1–2)

1 (1–3)

2 (0–2)

0.872

 DWMH, Fazekas scale

1 (0–1.5)

1 (0–2)

1 (0–2.75)

1 (0–1)

0.834

 Number of chronic lacunes

1 (0–3)

0 (0–2)

1 (0–2.75)

1 (0–2)

0.255

 Number of microbleeds

0 (0–2.5)

0 (0–1)

1 (0–2)

0 (0–2)

0.869

Laboratory findings (mean ± sd)

 

 Hemoglobin, g/dL

14.9 ± 1.8

13.9 ± 1.9

13.6 ± 1.7

13.7 ± 1.9

0.129

 Hematocrit, %

43.4 ± 5.2

40.9 ± 5.0

39.8 ± 4.4

40.0 ± 5.0

0.135

 White blood cells, 103/μL

7.2 ± 2.0

7.6 ± 2.9

9.5 ± 3.6

6.8 ± 2.6

0.110

 Platelets, 103/μL

238 ± 56

227 ± 48

233 ± 80

199 ± 40

0.700

 Total protein, gm/dL

7.1 ± 0.5

7.0 ± 0.4

7.2 ± 0.5

7.2 ± 0.1

0.429

 Fibrinogen, mg/dL

323 ± 78

335 ± 71

357 ± 70

215 ± 44

0.099

 D-dimer, μg/dL

0.44 ± 0.32

0.75 ± 0.92

1.51 ± 1.93

0.28 ± 0.10

0.038**

 BUN/Cr ratio

19.0 ± 4.6

23.1 ± 8.2

21.1 ± 5.3

17.3 ± 5.1

0.115

 Total cholesterol, mg/dL

176 ± 36

177 ± 28

155 ± 56

140 ± 32

0.192

 Low-density lipoprotein, mg/dL

109 ± 32

108 ± 22

94 ± 50

80 ± 30

0.319

 Triglycerides, mg/dL

127 ± 61

116 ± 80

70 ± 60

60 ± 35

0.078

  1. Abbreviations: SAO small artery occlusion, LAA large artery atherosclerosis, CE cardioembolism, Cryp cryptogenic stroke, sd standard deviation, IQR interquartile range, PVH periventricular hyperintensity, DWMH deep white matter hyperintensity, BUN/Cr blood urea nitrogen-to-creatinine
  2. *, p = 0.021, SAO vs. LAA in the post-hoc test; **, p = 0.027, SAO vs. CE in the post-hoc test