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Table 3 Health care costs and resource use in the 1-year pre-index period

From: Health care cost associated with the use of enzyme-inducing and non-enzyme–active antiepileptic drugs in the UK: a long-term retrospective matched cohort study

 

Overall population

Matched population

EIAED

(n = 2752)

nEAAED

(n = 2137)

p valuea

EIAED

(n = 951)

nEAAED

(n = 951)

p valuea

All-cause direct health care costs in the 1-year pre-index period, £

 Mean (SD)

5618 (7387)

4613 (6007)

<0.0001

4540 (6765)

4416 (5944)

0.6724

 Median (P10–P90)

3014 (495–14,070)

2516 (568–11,657)

 

2333 (452–10,863)

2283 (448–11,180)

 

Epilepsy-related direct health care costs in the 1-year pre-index period, £

 Mean (SD)

997 (2361)

633 (1965)

<0.0001

804 (2134)

726 (2201)

0.4314

 Median (P10–P90)

42 (0–2797)

11 (0–2188)

 

23 (0–2599)

11 (0–2599)

 

Health care resource use per patient in the 1-year pre-index period

Mean (SD) number of:

 GP practice consultations

35.13 (29.55)

43.69 (36.33)

<0.0001

36.48 (31.92)

37.04 (31.15)

0.6973

 A&E visits

0.83 (1.26)

0.70 (1.28)

0.0003

0.72 (1.41)

0.70 (1.15)

0.6173

 Outpatient non-A&E referrals

0.96 (1.45)

1.27 (1.40)

<0.0001

1.08 (1.35)

1.08 (1.29)

0.9446

 Inpatient hospitalizations

1.64 (5.63)

1.20 (2.70)

0.0004

1.44 (7.27)

1.22 (3.41)

0.4126

Hospitalization duration, mean (SD), days

 

6.96 (19.70)

3.64(11.89)

<0.0001

4.30 (11.32)

4.09 (11.48)

0.6873

  1. Abbreviations: A&E accident and emergency, EIAED enzyme-inducing antiepileptic drug, GP general practitioner, nEAAED non-enzyme–active antiepileptic drug, P10–P90 10th to 90th percentile, SD standard deviation. a t test