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Fig. 4 | BMC Neurology

Fig. 4

From: Concordance analysis of microarray studies identifies representative gene expression changes in Parkinson’s disease: a comparison of 33 human and animal studies

Fig. 4

Hierarchical clustering of studies based on the most highly differentially expressed genes in each PD study. Clustering was performed based on the union of the top 10 genes by absolute log-fold change across the 33 studies. The highlighted cluster contains all but one of the human studies of the substantia nigra, as well as both human frontal cortex studies. This indicates a distinct differential gene expression pattern that is shared by these study types. This cluster also contains one rat study, however, indicating that it is possible for animal models to capture the expression patterns observed here. Aside from this outgroup, there is no apparent clustering of other factors such as platform, disease model, or treatment (e.g., with L-DOPA), reflecting the low concordance seen in these groups

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