Ipsilateral and contralateral sensory changes in healthy subjects after experimentally induced concomitant sensitization and hypoesthesia

Table 1 Clinical data

	Part 1. Single substance application		Part 2. Combined substance application^a
	Cap-group	LA-group	Cap/LA-group	LA/Cap-group
	(n = 14)	(n = 14)	(n = 14)	(n = 14)
gender (female, n (%))	9 (64%)	8 (57%)	9 (64%)	8 (57%)
age (years, mean ± SD)	30 ± 14	30 ± 13	31 ± 13	30 ± 14
BMI (kg/m²)	23 ± 2	24 ± 4	23 ± 3	24 ± 3
HADS A-Score	3.9 ± 2.3	2.9 ± 2.0	2.9 ± 2.1	3.8 ± 2.3
HADS D-Score	1.5 ± 1.6	0.6 ± 0.9	0.9 ± 1.2	1.3 ± 1.5
Pain sensitivity score (PSQ), total	2.7 ± 0.9	2.5 ± 0.9	2.5 ± 0.8	2.7 ± 1
Pain catastrophizing scale (PCS), total	7.1 ± 8.2	10.1 ± 7.4	8.5 ± 7.7	8.6 ± 8.2
Duration of acute capsaicin-induced pain (min)	32 ± 7***	not applicable	83 ± 30.8***	48 ± 14***^c
Mean spontaneous pain intensity after capsaicin gauze removal (NRS 0-10)	6.7 ± 1.3	not applicable	6.7 ± 1.8	6.4 ± 1.9
Duration of reported hypersensitivity after capsaicin application (days)	1 ± 0.5	not applicable	0.8 ± 0.5	0.9 ± 0.5
Area of allodynia (cm²)	60 ± 39*	not applicable	32 ± 22*	48 ± 17*
Area of pinprick hyperalgesia (cm²)	66 ± 43	not applicable	57 ± 30	54 ± 25
Area of tactile hypoesthesia (cm²)	not applicable	9 ± 4	not applicable	not applicable
Skin temperature change after removal of the applied substances (Δ °C)^b	1.4 ± 1.4	-1.1 ± 1.1**	0.7 ± 1.5	1.8 ± 1.7

Cap single capsaicin application, LA single local anesthetics application, Cap/LA combined application of 1. capsaicin and 2. local anesthetic, LA/Cap combined application of 1. local anesthetic and 2. Capsaicin, HADS hospital anxiety and depression score, HADS-A-Score anxiety score, HADS-D-Score depression score, SD standard deviation
^aParticipants of the first part of the experiment are also involved in the second part. Therefore, values on the demographic characteristics, HADS, PSQ and PCS are redistributed for the data presentation of the part 2 of the study
^bPositive values indicate higher skin temperature after the substance application, negative values - lower temperature, respectively
^cThe mean value for the duration of acute capsaicin-induced pain was calculated only based on 5 subjects, the rest 9 subjects were still sensing ongoing pain at the end of the study procedures
*Significant difference (p < 0.05) between all three groups (ANOVA)
***Significant difference (p < 0.001) between all three groups (ANOVA)

ISSN: 1471-2377