Fig. 5

Statistical assessments of three metabolites indicative of FMS: (a) Volcano plot mapped by the scaled fold change and p-values for the 20 metabolites observed for FMS patients and young controls. Metabolites with high FC and significant p-values among patients are indicated by black squares. (b) ROC analyses for discriminating FMS patients from controls (AUROC) as well as leave-one-out crossvalidated ROC analysis (CV AUROC). The discriminator consisted of the three informative metabolites (succinic acid, taurine and creatine) identified by multivariate, univariate and metabolic pathway analyses