A diagnostic biomarker profile for fibromyalgia syndrome based on an NMR metabolomics study of selected patients and controls

Table 1 Univariate, multivariate and descriptive statistics for the 20 bins, comparing FMS and CN

Variable	CS and M[Ps]	VIP	Mann-Whitney		Fold Change	Mean		StDev
Variable	CS and M[Ps]	3 LV	p-value	Effect size	Fold Change	CN	FMS	CN	FMS
2-Hydroxyisobutyric acid	1.44 s [CH3]	6.26	0.0001	0.72	−1.56	0.01	0.02	0.0	0.00
Succinic acid	2.66 s [(CH2)2]	0.25	0.0001	0.61	−1.63	0.02	0.03	0.01	0.01
Taurine	3.25 t [CH2]	5.21	0.0007	0.52	−2.29	0.20	0.45	0.05	0.57
Tyrosine	6.89 dd [(CH)2]	0.37	0.0029	0.45	−1.70	0.03	0.06	0.03	0.06
Lactic acid	1.41 d [CH3]	2.83	0.0044	0.42	−1.81	0.06	0.11	0.03	0.07
Creatine	3.05 s [CH3]	4.40	0.0053	0.41	−2.08	0.05	0.09	0.04	0.08
TMAO	3.54 s [(CH3)3]	2.21	0.0062	0.41	−2.10	0.06	0.14	0.06	0.23
Dimethylglycine	2.93 s [(CH3)2]	0.00	0.0127	0.36	−1.29	0.01	0.01	0.00	0.00
Leucine	0.95 t [(CH3)2]	0.00	0.0136	0.36	−1.11	0.01	0.02	0.00	0.00
Formic acid	8.25 s [CH]	0.01	0.0361	0.29	−1.15	0.03	0.03	0.01	0.01
Valine	1.04 d [CH3]	0.00	0.0436	0.28	−1.24	0.01	0.01	0.00	0.00
Histamine	8.70 d [CH]	0.08	0.0436	0.28	−1.29	0.06	0.07	0.06	0.05
N-acetyl-X	2.03 s [CH3]	0.02	0.0464	0.27	−1.28	0.01	0.02	0.00	0.01
Lysine	1.73 m [CH2]	0.61	0.0739	0.23	−1.03	0.11	0.12	0.03	0.06
Hippuric acid	4.18 d [CH2]	1.61	0.0966	0.21	−1.55	0.22	0.35	0.10	0.24
Citric acid	2.89 AB [(CH)4]	1.36	0.1070	0.20	−1.21	0.39	0.47	0.16	0.17
Alanine	1.51 d [CH3]	0.13	0.1785	0.15	−1.16	0.06	0.07	0.02	0.03
Histidine	8.68 d [CH]	0.85	0.1942	0.14	1.19	0.07	0.06	0.04	0.04
Carnitine	3.22 s [(CH3)3]	0.02	0.2107	0.13	−1.24	0.02	0.02	0.01	0.01
Threonine	1.33 d [CH3]	0.04	0.2648	0.10	−1.28	0.03	0.04	0.01	0.04
3-Hydroxyisovaleric acid	1.33 s [(CH3)2]	0.00	0.4942	0.00	−1.02	0.00	0.00	0.00	0.00

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