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Table 2 Simple and multiple linear regression analyses estimating the relationship of patient characteristics with composite neurocognitive function, QNPZ-8 score

From: Neurocognitive function in HIV-infected persons with asymptomatic cryptococcal antigenemia: a comparison of three prospective cohorts

Variable

N

Unadjusted univariate estimatea

95% confidence interval

P -value

Adjusted estimatea

95% confidence interval

P -value

Study Population

302

      

 Cryptococcal meningitis (N = 90)

 

−0.42

(−0.74, −0.09)

0.01

−0.26

(−0.59, 0.07)

0.12

 Asymptomatic CRAG (N = 87)

 

Referent

- -

 

Referent

- -

 

 HIV positive controls (N = 125)

 

0.44

(0.14, 0.74)

0.004

0.42

(0.03, 0.81)

0.04

Age (per 10 years)

302

−0.20

(−0.37, −0.03)

0.02

−0.31

(−0.48, −0.15)

<0.001

Gender (Men as referent group)

302

0.01

(−0.25, 0.27)

0.94

−0.21

(−0.47, 0.04)

0.11

CD4 count (per 100 increase)

290

0.16

(0.07, 0.26)

0.001

0.02

(−0.10, 0.14)

0.79

Depressionb

300

−0.77

(−1.02, −0.53)

<0.001

−0.56

(−0.82, −0.30)

<0.001

  1. aEach estimate corresponds with the change in QNPZ-8 score for each incremental change in the variable
  2. bDepression modeled as a binary variable comparing using CES-D score > = 16 versus <16 as referent