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Table 1 Experiments completed for each study (i.e. set of animals)

From: Sex differences underlying orofacial varicella zoster associated pain in rats

Study Experiment Groups Number of animals
(male Sprague Dawley rats unless otherwise indicated)
Study #1 Thermal and mechanical hypersensitivity assay (Figure 3).
Neurite retraction study using PGP 9.5 (n = 3/group randomly selected, Figure 2).
Mewo (control)
Poka (VZV)
n = 10
n = 10
Study #2 Place escape/avoidance paradigm (Figure 4).
VZV infection detected with IE62 marker (Figure 1).
PBS (vehicle)
Mewo (control)
Poka (VZV virus)
n = 6
n = 6
n = 6
Study #3 Gabapentin assay (Figure 5). Mewo/vehicle
Mewo/gabapentin
Poka/vehicle
Poka/gabapentin
n = 5
n = 5
n = 5
n = 5
Study #4 Sex differences study comparing males and females (Figure 6). Mewo/female
Mewo/male
Poka/female
Poka/male
n = 24
n = 7–15
n = 25
n = 7–15
Study #5 OVX females as compared to males (Sprague Dawley and Long Evans, Figure 7).
VZV infection detected with IE62 marker (Sprague-Dawley rats, no figure).
Mewo/male
Mewo/female
Mewo/OVX female
Poka/male
Poka/female
Poka/OVX female
n = 5
n = 4
n = 4
n = 7
n = 6
n = 6
n = 5 (Long Evans) for all treatment groups
Study #6 Female estrous cycle study (Figure 8). Mewo diestrus
Mewo proestrus/estrus
Poka diestrus
Poka proestrus/estrus
n ≥ 8
n ≥ 8
n ≥ 8
n ≥ 8