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Fig. 4 | BMC Neurology

Fig. 4

From: Fatal familial insomnia with abnormal signals on routine MRI: a case report and literature review

Fig. 4

Pathological results of biopsy from the head of the right caudate nucleus. a Hematoxylin and eosin staining showed neuronal degeneration, as well as spongiform changes in the brain tissue. b A portion of neurons were stained by PRNP antibody (black arrows). c Gliosis was observed after staining with GFAP antibody (white arrows). d Degenerated neurons were observed under electron microscope. e Thickening of the walls and hyalinization of small blood vessels in the brain tissue were apparent. f Immunohistological staining showed no perivascular PRNP protein deposition. g Congo red staining of the small cerebral vessels was negative. Bar = 25 μm. h Multiple granular osmiophilic material depositions on the surface of vascular smooth muscle cells (white arrows) were observed under transmission electron microscopy examinations

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