Table 3 Estimated treatment effects for secondary outcomes at each time point from linear mixed effects model and effect sizes

Modified Fatigue Impact Scale

Post Intervention

Three month follow up

Six month follow up

1.05

−0.11

4.39

3.32

3.49

3.41

(−5.56, 7.65)

(−7.05, 6.82)

(−2.38, 11.17)

0.75

0.97

0.20

−0.12 (−0.61, 0.36)

−0.04 (−0.52, 0.45)

−0.25 (−0.74, 0.24)

Multiple Sclerosis Impact Scale29 - physical

Post Intervention

Three month follow up

Six month follow up

−2.58

−2.34

−0.54

3.26

3.45

3.35

(−9.06, 3.89)

(−9.19, 4.51)

(−7.19, 6.10)

0.43

0.50

0.87

0.06 (−0.43, 0.55)

−0.01 (−0.50, 0.47)

−0.02 (−0.51, 0.47)

Multiple Sclerosis Impact Scale29 - psychological

Post Intervention

Three month follow up

Six month follow up

−3.01

−5.26

3.90

4.39

4.71

4.54

(−11.71, 5.70)

(−14.59, 4.06)

(−5.09, 12.90)

0.50

0.27

0.39

0.25 (−0.24, 0.73)

0.34 (−0.15, 0.83)

−0.11 (−0.60, 0.37)

Hospital Anxiety Depression Scale-Anxiety

Post Intervention

Three month follow up

Six month follow up

−0.92

−0.93

0.01

0.91

0.95

0.93

(−2.72, 0.88)

(−2.81, 0.92)

(−1.83, 1.86)

0.31

0.33

0.99

0.34 (−0.15, 0.83)

0.37 (−0.12, 0.86)

0.17 (−0.32, 0.66)

Hospital Anxiety Depression Scale-Depression

Post Intervention

Three month follow up

Six month follow up

0.45

0.43

0.10

0.77

0.81

0.79

(−1.08, 1.97)

(−1.18, 2.03)

(−1.46, 1.66)

0.56

0.60

0.90

0.12 (−0.37, 0.60)

0.20 (−0.28, 0.69)

0.23 (−0.26, 0.72)

Symbol Digit Modality Test

Post Intervention

Three month follow up

Six month follow up

−3.03

4.93

−0.55

2.34

2.49

2.51

(−7.70, 1.64)

(−0.02, 9.87)

(−5.54, 4.44)

0.20

0.05

0.83

0.06 (−0.42, 0.55)

0.75 (0.24, 1.25)

0.15 (−0.34, 0.63)

5xSit To Stand

Post Intervention

Three month follow up

Six month follow up

0.06

−0.09

−0.62

0.45

0.48

0.48

(−0.84, 0.97)

(−1.10, 0.86)

(−1.60, 0.33)

0.89

0.85

0.20

0.11 (−0.37, 0.60)

0.41 (−0.08, 0.91)

0.49 (−0.003, 0.98)

Modified Canadian Aerobic Fitness Test

Post Intervention

Three month follow up

Six month follow up

−7.02

16.12

10.53

9.75

10.63

10.90

(−26.45, 12.41)

(−5.03, 37.26)

(−11.13, 32.19)

0.47

0.13

0.34

−0.08 (−0.57, 0.40)

0.51 (0.01, 1.00)

0.34 (−0.15, 0.83)

Godin Leisure Time Exercise Questionnaire – Health Index

Post Intervention

Three month follow up

Six month follow up

−2.24

0.42

0.11

4.55

4.75

4.64

(−11.30, 6.82)

(−9.02, 9.87)

(−9.12, 9.34)

0.62

0.93

0.98

−0.32 (−0.81, 0.17)

−0.13 (−0.62, 0.36)

0.06 (−0.42, 0.55)

Mean steps per day

Post Intervention

Three month follow up

Six month follow up

−163.35

−439.08

448.87

696.12

703.49

737.27

(−1552.20, 1225.50)

(−1842.34, 964.19)

(−1020.74, 1918.48)

0.81

0.53

0.54

−0.14 (−0.63, 0.35)

0.06 (−0.42, 0.55)

0.08 (−0.57, 0.40)

Mean Energy Expenditure per day

Post Intervention

Three month follow up

Six month follow up

114.42

53.61

63.47

95.05

98.07

103.30

(−74.65, 303.48)

(−141.39, 248.61)

(−141.84, 268.78)

0.23

0.59

0.54

0.39 (−0.10, 0.88)

0.40 (−0.09, 0.89)

0.12 (−0.36, 0.61)

Exercise Benefits Questionnaire

Post Intervention

Three month follow up

Six month follow up

0.311

1.01

0.11

3.01

3.09

3.05

(−5.34, 6.23)

(−5.16, 7.19)

(−5.98, 6.20)

0.84

0.74

0.97

−0.10 (−0.59, 0.38)

−0.11 (−0.60, 0.37)

−0.19 (−0.68, 0.29)

Exercise Barriers Questionnaire

Post Intervention

Three month follow up

Six month follow up

−0.24

0.73

0.67

1.07

1.12

1.09

(−2.37, 1.88)

(−1.50, 2.96)

(−1.50, 2.85)

0.82

0.52

0.54

0.08 (−0.41, 0.57)

−0.24 (−0.73, 0.25)

−0.14 (−0.63, 0.35)

Multidimensional Outcomes Expectations for Exercise Scale total

Post Intervention

Three month follow up

Six month follow up

−0.42

1.31

1.13

1.56

1.63

1.59

(−3.52, 2.68)

(−1.93, 4.55)

(−2.03, 4.30)

0.79

0.42

0.48

−0.18 (−0.67, 0.30)

0.03 (−0.46, 0.52)

0.02 (−0.47, 0.50)

Exercise Goal setting Questionnaire

Post Intervention

Three month follow up

Six month follow up

2.03

−0.50

−0.26

2.15

2.30

2.21

(−2.24, 6.30)

(−5.05, 4.06)

(−4.65, 4.13)

0.35

0.83

0.91

0.07 (−0.42, 0.56)

−0.21 (−0.69, 0.28)

−0.27 (−0.76, 0.21)

Exercise Planning Questionnaire

Post Intervention

Three month follow up

Six month follow up

2.08

1.86

0.77

1.74

1.84

1.79

(−1.38, 5.34)

(−1.78, 5.51)

(−2.77, 4.32)

0.24

0.31

0.67

0.34 (−0.15, 0.83)

0.31 (−0.18, 0.80)

0.17 (−0.32, 0.66)

Exercise Self-efficacy

Post Intervention

Three month follow up

Six month follow up

−3.89

3.01

1.66

7.17

7.48

7.31

(−18.15, 10.38)

(−11.86, 17.88)

(−12.88, 16.20)

0.59

0.69

0.82

−0.07 (−0.55, 0.42)

0.33 (−0.16, 0.82)

0.28 (−0.21, 0.77)

Social Provisions Scale total

Post Intervention

Three month follow up

Six month follow up

1.69

2.79

1.15

1.82

1.91

1.86

(−1.94, 5.32)

(−0.10, 6.58)

(−2.55, 4.85)

0.36

0.15

0.54

0.40 (−0.09, 0.90)

0.49 (−0.005, 0.98)

0.45 (−0.05, 0.94)