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Table 2 Number and type of cancer by IS drug and by exposure duration

From: Association between multiple sclerosis, cancer risk, and immunosuppressant treatment: a cohort study

Drug

Exposure duration (years)

No. of patients

N. and site of cancer

p*

Azathioprine

< 4

169

3 (gut a, brain, ovary)

 

≥4

177

4 (3 breast, 1 guta)

0,75

Mitoxantrone

<1

74

1 (pancreas)

 

≥1

188

5 (3 leukemia, 1 lung, 1 gut)

0,5

  1. * two sided Chi square analysis comparing the frequency among MS patients exposed for the longer period, compared to those exposed for a shorter period
  2. aGut cancers include colon and rectal cancers