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Fig. 3 | BMC Neurology

Fig. 3

From: Amyotrophic lateral sclerosis modifies progenitor neural proliferation in adult classic neurogenic brain niches

Fig. 3

Analysis of the percentage of pTDP-43 and its correlation to markers linked to proliferation and adult neurogenesis in the SVZ and hippocampus in controls and patients with ALS/ALS-FTD. a Significant direct linear correlation between the increase in gap layer thickness and the percentage of inclusions positive for pTDP-43. b Tendency toward a direct linear correlation between the increase in ribbon layer thickness and percentage of inclusions positive for pTDP-43. c Significant direct linear correlation between the increase in GFAP expression and the percentage of pTDAP-43 inclusions. d Significant direct linear correlation between the increase in PCNA protein expression in the SVZ and the percentage of inclusions positive for pTDP-43. e Significant direct linear correlation between the increase in Ki-67 protein (indicating proliferation in the SVZ) and the percentage of inclusions positive for pTDP-43. f Significant direct linear correlation between increased expression of the GFAPδ protein in the SVZ and the percentage of pTDP-43 inclusions. g Significant direct linear correlation between increased expression of PSA-NCAM (neuroblast marker) in the SVZ and the percentage of inclusions positive for pTDP-43. h Significant direct linear correlation between the increase in the expression of doublecortin (neuroblast marker) and the percentage of inclusions positive for pTDP-43 in the SVZ. i Significant direct linear correlation between the increase in the expression of hippocampal GFAP (marker for gliosis) and the percentage of inclusions positive for pTDP-43. j The hippocampus shows a significant inverse exponential relationship between the expression of PCNA (proliferation marker) and the percentage of pTDP-43–positive inclusions. k Significant inverse exponential relationship between hippocampal expression of the Ki-67 protein (proliferation marker) and the percentage of inclusions positive for pTDP-43. l Significant inverse exponential relationship between hippocampal expression of the GFAPδ protein and the percentage of inclusions positive for pTDP-43. m The hippocampus displays a significant inverse exponential relationship between the expression of the PSA-NCAM protein (neuroblast marker) and the percentage of pTDP-43 positive inclusions

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