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Table 1 Summary of bold responses for “heat pain only”, “heat pain combined with CT targeted touch” and “CT touch”, versus control condition showing MNI coordinates, cluster size and peak T-value for healthy subjects (A) and SFN patients (B)

From: Low threshold unmyelinated mechanoafferents can modulate pain

H

Brain region

MNI coordinate (x, y, z)

cluster size

peak T-value

A. Bold responses (healthy subjects)

Heat pain

R

Insula (ant)

33, 23, 1

25

10.0226202

R

Middle frontal gyrus, BA 40

45, 35, 25

16

9.40863228

R

Middle frontal gyrus

33, − 1, 55

13

8.20184994

R

Supramarginal gyrus, posterior division

57, − 37, 43

3

7.02497864

R

Inferior frontal gyrus, pars opercularis

48, 14, 13

21

8.32530499

R

Angular gyrus; S2*

45,- 49, 46

9

7.82689619

R

ACC

3, 26, 37

4

7.43887186

R

Paracingulate gyrus

6, 14, 46

58

8.13667107

L

Paracingulate gyrus

-6, 26, 34

8

7.75460911

L

Insula (ant)

− 30, 23, 1

21

10.1233358

L

Lateral globus pallidus*

− 18, 2, 1

4

8.00571537

Heat pain combined with CT targeted touch

R

Insula (ant.)

36, 26, − 5

63

8.555808067

R

ACC

0, 17, 49

45

7.733303547

R

Putamen

24, 2, 1

8

7.900562286

R

Supramarginal gyrus, BA 40; S2*

57, − 40, 31

19

8.539946556

R

Middle frontal gyrus, BA 40

36, 2, 49

8

7.389503002

R

Anterior intra-parietal sulcus hIP1

42, − 49, 46

10

7.324296474

R

Inferior frontal gyrus, BA 47

42, 20, − 11

3

7.169946671

R

Cerebellum

30, − 58, − 32

24

7.958759308

L

Insula (ant)

− 30, 23, − 2

38

8.298020363

L

Supramarginal gyrus, BA 40

− 42, − 34, 34

5

7.888269424

CT targeted touch

R

Parietal operculum

48, − 34, 31

3

7.85348225

L

Postcentral gyrus

− 57, − 25, 34

3

6.73631382

B. Bold responses (SFN patients)

Heat pain

R

Insula (med.-ant.)*

42, 17, − 2

7

7.24895525

R

ACC

3, 11, 46

42

8.66720772

R

Angular gyrus, BA 40; S2*

45,-46, 49

30

10.2263985

R

Precuneous cortex

15,-67, 43

20

8.95573997

R

Lateral occipital cortex

33, − 67, 40

8

8.75775337

R

Lateral occipital cortex

33, − 58, 46

18

8.02260399

R

Broca’s area, BA 44

54, 11, 1

4

8.00252247

R

Cerebellum, anterior lobe

27, − 55, − 20

4

7.94967175

R

Visual cortex, BA 17

18, − 97, 4

4

7.3528986

L

Insula (ant.)*

− 27, 20, − 5

5

8.33598518

L

Superior parietal lobule

− 30, − 52, 49

40

8.32214737

L

Anterior intra-parietal sulcus

− 36, − 43, 37

3

7.88397264

L

Supramarginal gyrus

− 51, − 37, 46

5

7.11958122

L

Frontal operculum

− 42, 17, − 2

13

9.18519974

L

Cerebellum, posterior lobe

− 27, − 62, − 29

42

10.7323313

L

Cerebellum, posterior lobe

− 6, − 76, − 23

22

8.34745884

L

Inferior cerebellum*

− 24, − 61, − 50

21

10.6803532

Heat pain combined with CT targeted touch

R

Supramarginal gyrus, BA 40; S2*

42, − 46, 46

168

9.750800133

R

Insula (mid-ant)

39, 17, − 2

48

9.569821358

R

Parietal operculum

60, − 28, 22

13

9.502679825

R

Precentral gyrus; S1*

48, 11, 31

14

8.683162689

R

Paracingulate gyrus

9, 14, 40

9

7.428187847

R

Cerebellum, anterior lobe (culmen)

9, − 49, − 17

3

6.953028679

R

Cerebellum, anterior lobe (culmen)

30, − 49, − 26

28

8.335325241

R

Broca’s area BA44

48, 14, 16

4

7.146142006

R

Visual cortex, BA 17

18, − 79, 10

4

6.931876659

L

Frontal operculum

− 48, 17, − 2

40

8.466537476

L

Paracingulate gyrus, premotor cortex BA 6

0, 8, 52

11

7.569615841

L

Precentral gyrus

− 57, 5, 4

8

9.12651825

L

Superior parietal lobule, anterior intra-parietal sulcus; S2*

− 36, − 49, 46

3

7.223741531

L

Supramarginal gyrus, postcentral gyrus

− 42, − 34, 4

12

8.600948334

L

Cerebellum, posterior lobe

− 33, − 64, − 44

12

8.533157349

L

Cerebellum, posterior lobe (Pyramis)

− 9, − 76, − 29

15

9.127865791

L

Cerebellum posterior lobe (Uvula)

− 21, − 67, − 26

6

7.966376305

L

Cerebellum, anterior lobe

− 36, − 55, − 29

32

8.700092316

CT targeted touch

R

Parietal operculum

48, − 31, 19

8

10.0452766

  1. All activations are shown with p (peak, FWE-corr) < 0.05 and cluster size ≥ 3
  2. *anatomical correspondence in SPM using template
  3. All activations are shown with p<0.05 (peak, FWE-correction) and cluster size≥3. Regions marked with * are named after their anatomical correspondence in SPM using the template avg152T2