From: Low threshold unmyelinated mechanoafferents can modulate pain
H | Brain region | MNI coordinate (x, y, z) | cluster size | peak T-value |
---|---|---|---|---|
A. Bold responses (healthy subjects) | ||||
Heat pain | ||||
R | Insula (ant) | 33, 23, 1 | 25 | 10.0226202 |
R | Middle frontal gyrus, BA 40 | 45, 35, 25 | 16 | 9.40863228 |
R | Middle frontal gyrus | 33, − 1, 55 | 13 | 8.20184994 |
R | Supramarginal gyrus, posterior division | 57, − 37, 43 | 3 | 7.02497864 |
R | Inferior frontal gyrus, pars opercularis | 48, 14, 13 | 21 | 8.32530499 |
R | Angular gyrus; S2* | 45,- 49, 46 | 9 | 7.82689619 |
R | ACC | 3, 26, 37 | 4 | 7.43887186 |
R | Paracingulate gyrus | 6, 14, 46 | 58 | 8.13667107 |
L | Paracingulate gyrus | -6, 26, 34 | 8 | 7.75460911 |
L | Insula (ant) | − 30, 23, 1 | 21 | 10.1233358 |
L | Lateral globus pallidus* | − 18, 2, 1 | 4 | 8.00571537 |
Heat pain combined with CT targeted touch | ||||
R | Insula (ant.) | 36, 26, − 5 | 63 | 8.555808067 |
R | ACC | 0, 17, 49 | 45 | 7.733303547 |
R | Putamen | 24, 2, 1 | 8 | 7.900562286 |
R | Supramarginal gyrus, BA 40; S2* | 57, − 40, 31 | 19 | 8.539946556 |
R | Middle frontal gyrus, BA 40 | 36, 2, 49 | 8 | 7.389503002 |
R | Anterior intra-parietal sulcus hIP1 | 42, − 49, 46 | 10 | 7.324296474 |
R | Inferior frontal gyrus, BA 47 | 42, 20, − 11 | 3 | 7.169946671 |
R | Cerebellum | 30, − 58, − 32 | 24 | 7.958759308 |
L | Insula (ant) | − 30, 23, − 2 | 38 | 8.298020363 |
L | Supramarginal gyrus, BA 40 | − 42, − 34, 34 | 5 | 7.888269424 |
CT targeted touch | ||||
R | Parietal operculum | 48, − 34, 31 | 3 | 7.85348225 |
L | Postcentral gyrus | − 57, − 25, 34 | 3 | 6.73631382 |
B. Bold responses (SFN patients) | ||||
Heat pain | ||||
R | Insula (med.-ant.)* | 42, 17, − 2 | 7 | 7.24895525 |
R | ACC | 3, 11, 46 | 42 | 8.66720772 |
R | Angular gyrus, BA 40; S2* | 45,-46, 49 | 30 | 10.2263985 |
R | Precuneous cortex | 15,-67, 43 | 20 | 8.95573997 |
R | Lateral occipital cortex | 33, − 67, 40 | 8 | 8.75775337 |
R | Lateral occipital cortex | 33, − 58, 46 | 18 | 8.02260399 |
R | Broca’s area, BA 44 | 54, 11, 1 | 4 | 8.00252247 |
R | Cerebellum, anterior lobe | 27, − 55, − 20 | 4 | 7.94967175 |
R | Visual cortex, BA 17 | 18, − 97, 4 | 4 | 7.3528986 |
L | Insula (ant.)* | − 27, 20, − 5 | 5 | 8.33598518 |
L | Superior parietal lobule | − 30, − 52, 49 | 40 | 8.32214737 |
L | Anterior intra-parietal sulcus | − 36, − 43, 37 | 3 | 7.88397264 |
L | Supramarginal gyrus | − 51, − 37, 46 | 5 | 7.11958122 |
L | Frontal operculum | − 42, 17, − 2 | 13 | 9.18519974 |
L | Cerebellum, posterior lobe | − 27, − 62, − 29 | 42 | 10.7323313 |
L | Cerebellum, posterior lobe | − 6, − 76, − 23 | 22 | 8.34745884 |
L | Inferior cerebellum* | − 24, − 61, − 50 | 21 | 10.6803532 |
Heat pain combined with CT targeted touch | ||||
R | Supramarginal gyrus, BA 40; S2* | 42, − 46, 46 | 168 | 9.750800133 |
R | Insula (mid-ant) | 39, 17, − 2 | 48 | 9.569821358 |
R | Parietal operculum | 60, − 28, 22 | 13 | 9.502679825 |
R | Precentral gyrus; S1* | 48, 11, 31 | 14 | 8.683162689 |
R | Paracingulate gyrus | 9, 14, 40 | 9 | 7.428187847 |
R | Cerebellum, anterior lobe (culmen) | 9, − 49, − 17 | 3 | 6.953028679 |
R | Cerebellum, anterior lobe (culmen) | 30, − 49, − 26 | 28 | 8.335325241 |
R | Broca’s area BA44 | 48, 14, 16 | 4 | 7.146142006 |
R | Visual cortex, BA 17 | 18, − 79, 10 | 4 | 6.931876659 |
L | Frontal operculum | − 48, 17, − 2 | 40 | 8.466537476 |
L | Paracingulate gyrus, premotor cortex BA 6 | 0, 8, 52 | 11 | 7.569615841 |
L | Precentral gyrus | − 57, 5, 4 | 8 | 9.12651825 |
L | Superior parietal lobule, anterior intra-parietal sulcus; S2* | − 36, − 49, 46 | 3 | 7.223741531 |
L | Supramarginal gyrus, postcentral gyrus | − 42, − 34, 4 | 12 | 8.600948334 |
L | Cerebellum, posterior lobe | − 33, − 64, − 44 | 12 | 8.533157349 |
L | Cerebellum, posterior lobe (Pyramis) | − 9, − 76, − 29 | 15 | 9.127865791 |
L | Cerebellum posterior lobe (Uvula) | − 21, − 67, − 26 | 6 | 7.966376305 |
L | Cerebellum, anterior lobe | − 36, − 55, − 29 | 32 | 8.700092316 |
CT targeted touch | ||||
R | Parietal operculum | 48, − 31, 19 | 8 | 10.0452766 |