Effects of Homocysteine on white matter diffusion parameters in Alzheimer’s disease

Lee, Chen-Chang; Hsu, Shih-Wei; Huang, Chi-Wei; Chang, Wen-Neng; Chen, Sz-Fan; Wu, Ming-Kung; Chang, Chiung-Chih; Hwang, Lain-Chyr; Chen, Po-Chou

doi:10.1186/s12883-017-0970-7

BMC Neurology

Table 2 Comparisons of diffusion parameters using 11 association Fibers

From: Effects of Homocysteine on white matter diffusion parameters in Alzheimer’s disease

Fiber name	Mean ± SD			Hcy	Hcy Adjusted^a
Forceps.major
Fractional Anisotropy	0.475	±	0.041	−0.415*	−0.358*
Axial Diffusivity(×10⁻³)	1.487	±	0.136	0.227*	0.060
Radial Diffusivity(×10⁻³)	0.696	±	0.129	0.339*	0.214
Mean Diffusivity(×10⁻³)	0.960	±	0.128	0.307*	0.164
Forceps.minor
Fractional Anisotropy	0.351	±	0.026	−0.351*	−0.258*
Axial Diffusivity(×10⁻³)	1.415	±	0.066	0.216	0.053
Radial Diffusivity(×10⁻³)	0.820	±	0.070	0.328*	0.173
Mean Diffusivity(×10⁻³)	1.018	±	0.067	0.301*	0.139
Anterior.thalamic.radiation
Fractional Anisotropy	0.605	±	0.056	−0.339*	−0.248*
Axial Diffusivity(×10⁻³)	3.052	±	0.440	0.346*	0.179
Radial Diffusivity(×10⁻³)	2.049	±	0.414	0.356*	0.198
Mean Diffusivity(×10⁻³)	2.383	±	0.422	0.353*	0.192
Corticospinal.tract
Fractional Anisotropy	0.992	±	0.055	−0.282*	−0.302*
Axial Diffusivity(×10⁻³)	2.619	±	0.111	0.456*	0.349*
Radial Diffusivity(×10⁻³)	1.191	±	0.118	0.442*	0.388*
Mean Diffusivity(×10⁻³)	1.667	±	0.110	0.467*	0.393*
Cingulum._cingulate.gyrus
Fractional Anisotropy	0.677	±	0.062	−0.329*	−0.231*
Axial Diffusivity(×10⁻³)	2.272	±	0.091	−0.053	−0.022
Radial Diffusivity(×10⁻³)	1.379	±	0.105	0.214*	0.154
Mean Diffusivity(×10⁻³)	1.677	±	0.093	0.143*	0.108
Cingulum._hippocampus
Fractional Anisotropy	0.578	±	0.068	−0.177	−0.102
Axial Diffusivity(×10⁻³)	2.347	±	0.245	0.162	0.039*
Radial Diffusivity(×10⁻³)	1.540	±	0.231	0.177	0.066
Mean Diffusivity(×10⁻³)	1.809	±	0.233	0.173	0.057
Inferior.frontooccipital.fasciculus
Fractional Anisotropy	0.736	±	0.053	−0.364*	−0.343*
Axial Diffusivity(×10⁻³)	2.554	±	0.133	0.392*	0.285*
Radial Diffusivity(×10⁻³)	1.432	±	0.148	0.432*	0.357*
Mean Diffusivity(×10⁻³)	1.806	±	0.141	0.427*	0.340*
Inferior.longitudinal.fasciculus
Fractional Anisotropy	0.744	±	0.050	−0.343*	−0.292*
Axial Diffusivity(×10⁻³)	2.413	±	0.125	0.243*	0.186
Radial Diffusivity(×10⁻³)	1.350	±	0.126	0.343*	0.272*
Mean Diffusivity(×10⁻³)	1.704	±	0.123	0.317*	0.249*
Superior.longitudinal.fasciculus
Fractional Anisotropy	0.631	±	0.049	−0.266*	−0.281*
Axial Diffusivity(×10⁻³)	2.274	±	0.136	0.343*	0.218
Radial Diffusivity(×10⁻³)	1.456	±	0.140	0.356*	0.275*
Mean Diffusivity(×10⁻³)	1.729	±	0.137	0.357*	0.261*
Uncinate.fasciculus
Fractional Anisotropy	0.680	±	0.050	−0.282*	−0.246*
Axial Diffusivity(×10⁻³)	2.664	±	0.265	0.218	0.092
Radial Diffusivity(×10⁻³)	1.625	±	0.250	0.254*	0.152
Mean Diffusivity(×10⁻³)	1.971	±	0.253	0.243*	0.132
Superior.longitudinal.fasciculus temporal.part
Fractional Anisotropy	0.898	±	0.084	−0.321*	−0.398*
Axial Diffusivity(×10⁻³)	2.473	±	0.147	0.344*	0.293*
Radial Diffusivity(×10⁻³)	1.179	±	0.146	0.445*	0.466*
Mean Diffusivity(×10⁻³)	1.610	±	0.136	0.441*	0.438*

*p< 0.01
^aadjusted for glomerular filtration rate, creatinine, folate and vitamine B12 levels

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