Skip to main content

Table 3 Cognitive outcomes in relation to white matter integrities using fractional anisotropy adjusted for confounding factors

From: Effects of Homocysteine on white matter diffusion parameters in Alzheimer’s disease

Tract name

Simple correlation

Adjusted for confounders#

MMSE

CASI total

CASI EFT

STM

MMSE

CASI total

CASI EFT

STM

Forceps.major

.284(*)

.294(*)

.358(*)

.246(*)

.329(*)

.342(*)

.396(*)

.278(*)

Forceps.minor

.291(*)

.300(*)

.364(*)

.252(*)

.333(*)

.342(*)

.395(*)

.285(*)

Anterior.thalamic.radiation

.271(*)

.276(*)

.333(*)

.241(*)

.298(*)

.302(*)

.350(*)

.266(*)

Corticospinal.tract

.304(*)

.308(*)

.361(*)

.249(*)

.316(*)

.331(*)

.379(*)

.252(*)

Cingulum._cingulate.gyrus

.308(*)

.322(*)

.342(*)

.280(*)

.327(*)

.344(*)

.355(*)

.289(*)

Cingulum._hippocampus

.351(*)

.384(*)

.344(*)

.451(*)

.342(*)

.375(*)

.334(*)

.447(*)

Inferior.frontooccipital.fasciculus

.222

.241(*)

.314(*)

.213

.251(*)

.280(*)

.343(*)

.230(*)

Inferior.longitudinal.fasciculus

.266(*)

.290(*)

.350(*)

.214

.216

.240(*)

.280(*)

.193

Superior.longitudinal.fasciculus

.199

.219

.269(*)

.182

.252(*)

.260(*)

.263(*)

.252(*)

Uncinate.fasciculus

.241(*)

.243(*)

.256(*)

.251(*)

.295(*)

.323(*)

.372(*)

.230(*)

Superior.longitudinal.fasciculus.temporal.part

.161

.194

.248(*)

.103

.198

.241(*)

.279(*)

.128

  1. Numbers indicate Correlation Coefficient;
  2. *Correlation is significant at the 0.01 level (2-tailed)
  3. #Adjusted for homocysteine, vitamine B12, folate, creatinine, glomerular filtration rate;
  4. MMSE minimental state examination, CASI Cognitive Ability Screening Instrument, EFT Attention, verbal fluency, abstract thinking, and mental manipulation sub-domain scores of the CASI were added to assess executive function, STM short term memory from CASI