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Table 4 Cognitive outcomes in relation to white matter integrities using axial diffusivities adjusted for confounding factors

From: Effects of Homocysteine on white matter diffusion parameters in Alzheimer’s disease

Tract name

Simple correlation

Adjusted for confounders#

MMSE

CASI total

CASI EFT

STM

MMSE

CASI total

CASI EFT

STM

Forceps.major

−.220

−.213

−.207

−.138

−.228(*)

−.210

−.201

−.139

Forceps.minor

−.324(*)

−.325(*)

−.341(*)

−.250(*)

−.322(*)

−.320(*)

−.339(*)

−.242(*)

Anterior.thalamic.radiation

−.297(*)

−.306(*)

−.337(*)

−.273(*)

−.331(*)

−.335(*)

−.359(*)

−.308(*)

Corticospinal.tract

−.154

−.132

−.189

−.034

−.183

−.159

−.207

−.055

Cingulum._cingulate.gyrus

−.374(*)

−.387(*)

−.365(*)

−.314(*)

−.353(*)

−.368(*)

−.355(*)

−.294(*)

Cingulum._hippocampus

−.463(*)

−.468(*)

−.385(*)

−.486(*)

−.467(*)

−.468(*)

−.380(*)

−.484(*)

Inferior.frontooccipital.fasciculus

−.372(*)

−.350(*)

−.379(*)

−.241(*)

−.398(*)

−.379(*)

−.400(*)

−.250(*)

Inferior.longitudinal.fasciculus

−.430(*)

−.409(*)

−.371(*)

−.323(*)

−.443(*)

−.425(*)

−.377(*)

−.318(*)

Superior.longitudinal.fasciculus

−.392(*)

−.375(*)

−.363(*)

−.286(*)

−.416(*)

−.397(*)

−.376(*)

−.293(*)

Uncinate.fasciculus

−.319(*)

−.335(*)

−.294(*)

−.352(*)

−.331(*)

−.345(*)

−.296(*)

−.357(*)

Superior.longitudinal.fasciculus.temporal.part

−.234(*)

−.216

−.210

−.129

−.246(*)

−.234(*)

−.217

−.134

  1. Numbers indicate Correlation Coefficient;
  2. *Correlation is significant at the 0.01 level (2-tailed)
  3. #Adjusted for homocysteine, vitamine B12, folate, creatinine, glomerular filtration rate
  4. MMSE minimental state examination, CASI Cognitive Ability Screening Instrument, EFT Attention, verbal fluency, abstract thinking, and mental manipulation sub-domain scores of the CASI were added to assess executive function, STM short term memory from CASI