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Table 5 Cognitive outcomes in relation to white matter integrities using radial diffusivities adjusted for confounding factors

From: Effects of Homocysteine on white matter diffusion parameters in Alzheimer’s disease

Tract name

Simple correlation

Adjusted for confounders#

MMSE

CASI total

CASI EFT

STM

MMSE

CASI total

CASI EFT

STM

Forceps.major

−.269(*)

−.271(*)

−.296(*)

−.205

−.295(*)

−.290(*)

−.308(*)

−.220

Forceps.minor

−.357(*)

−.365(*)

−.405(*)

−.300(*)

−.383(*)

−.389(*)

−.423(*)

−.318(*)

Anterior.thalamic.radiation

−.302(*)

−.313(*)

−.349(*)

−.276(*)

−.340(*)

−.345(*)

−.373(*)

−.315(*)

Corticospinal.tract

−.273(*)

−.268(*)

−.325(*)

−.178

−.309(*)

−.310(*)

−.358(*)

−.203

Cingulum._cingulate.gyrus

−.430(*)

−.450(*)

−.459(*)

−.362(*)

−.430(*)

−.452(*)

−.458(*)

−.356(*)

Cingulum._hippocampus

−.471(*)

−.488(*)

−.419(*)

−.519(*)

−.474(*)

−.488(*)

−.415(*)

−.519(*)

Inferior.frontooccipital.fasciculus

−.321(*)

−.322(*)

−.377(*)

−.244(*)

−.361(*)

−.367(*)

−.413(*)

−.266(*)

Inferior.longitudinal.fasciculus

−.406(*)

−.407(*)

−.414(*)

−.314(*)

−.440(*)

−.444(*)

−.438(*)

−.327(*)

Superior.longitudinal.fasciculus

−.354(*)

−.356(*)

−.367(*)

−.276(*)

−.384(*)

−.386(*)

−.386(*)

−.292(*)

Uncinate.fasciculus

−.321(*)

−.340(*)

−.307(*)

−.360(*)

−.336(*)

−.355(*)

−.313(*)

−.369(*)

Superior.longitudinal.fasciculus.temporal.part

−.232(*)

−.246(*)

−.283(*)

−.139

−.277(*)

−.303(*)

−.324(*)

−.166

  1. Numbers indicate Correlation Coefficient
  2. *Correlation is significant at the 0.01 level (2-tailed)
  3. #Adjusted for homocysteine, vitamine B12, folate, creatinine, glomerular filtration rate
  4. MMSE minimental state examination, CASI Cognitive Ability Screening Instrument, EFT Attention, verbal fluency, abstract thinking, and mental manipulation sub-domain scores of the CASI were added to assess executive function, STM short term memory from CASI