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Table 6 Cognitive outcomes in relation to white matter integrities using mean diffusivities adjusted for confounding factors

From: Effects of Homocysteine on white matter diffusion parameters in Alzheimer’s disease

Tract name

Simple correlation

Adjusted for confounders#

MMSE

CASI total

CASI EFT

STM

MMSE

CASI total

CASI EFT

STM

Forceps.major

−.258(*)

−.257(*)

−.272(*)

−.186

−.278(*)

−.268(*)

−.277(*)

−.195

Forceps.minor

−.356(*)

−.362(*)

−.395(*)

−.292(*)

−.373(*)

−.377(*)

−.406(*)

−.301(*)

Anterior.thalamic.radiation

−.301(*)

−.311(*)

−.346(*)

−.275(*)

−.338(*)

−.342(*)

−.369(*)

−.313(*)

Corticospinal.tract

−.246(*)

−.235(*)

−.294(*)

−.139

−.284(*)

−.276(*)

−.326(*)

−.164

Cingulum._cingulate.gyrus

−.442(*)

−.461(*)

−.461(*)

−.372(*)

−.433(*)

−.454(*)

−.454(*)

−.359(*)

Cingulum._hippocampus

−.474(*)

−.487(*)

−.412(*)

−.514(*)

−.478(*)

−.488(*)

−.409(*)

−.514(*)

Inferior.frontooccipital.fasciculus

−.342(*)

−.336(*)

−.383(*)

−.247(*)

−.379(*)

−.378(*)

−.416(*)

−.265(*)

Inferior.longitudinal.fasciculus

−.424(*)

−.417(*)

−.409(*)

−.324(*)

−.452(*)

−.448(*)

−.428(*)

−.332(*)

Superior.longitudinal.fasciculus

−.372(*)

−.368(*)

−.372(*)

−.284(*)

−.401(*)

−.396(*)

−.389(*)

−.297(*)

Uncinate.fasciculus

−.249(*)

−.253(*)

−.277(*)

−.145

−.337(*)

−.354(*)

−.309(*)

−.367(*)

Superior.longitudinal.fasciculus.temporal.part

−.258(*)

−.257(*)

−.272(*)

−.186

−.288(*)

−.302(*)

−.310(*)

−.167

  1. *Correelation is significant at the 0.01 level (2-tailed)
  2. #Adjusted for homocysteine, vitamine B12, folate, creatinine, glomerular filtration rate
  3. MMSE minimental state examination, CASI Cognitive Ability Screening Instrument, EFT Attention, verbal fluency, abstract thinking, and mental manipulation sub-domain scores of the CASI were added to assess executive function, STM short term memory from CASI