Table 1 Demographic characteristics of the studied population

Controls (432)

Cases (829)

Controls (139)

Cases (336)

Controls (293)

Cases (493)

Females, n (%)

197 (45.60)

278 (33.53)

94 (67.63)

116 (34.52)

166 (56.66)

162 (32.86)

Age at Onset (years)

–

60.99

–

62.50

–

61.00

Age at Last Assessment (years)

63.60

64.70

61.30

61.74

64.86

67.40

Age at Lumbar Puncture (years)

62.73

63.61

63.04

63.07

60.60

65.65

Family History of PD, n (%)

11 (2.55)

211 (25.45)

8 (5.76)

79 (23.51)

3 (1.02)

132 (26.77)

Controls (155)

Cases (422)

Controls (135)

Cases (334)

Controls (20)

Cases (88)

α-syn (pg/mL ± SD)

829.30 ± 853.67

1800.90 ± 706.85

2173.5 ± 800.80

1865 ± 717.65

1725 ± 453.77

1556.20 ± 608.45

Aβ_1–42 (pg/mL ± SD)

−0.004 ± 0.12^a

−0.013 ± 0.12^a

378.40 ± 104.37

377.30 ± 99.63

926.40 ± 148.02

808.30 ± 215.07

t-tau (pg/mL ± SD)

0.021 ± 0.18^a

−0.038 ± 0.16^a

53.95 ± 22.90

46.18 ± 18.77

250.40 ± 113.58

222.87 ± 85.34

p-tau (pg/mL ± SD)

−0.004 ± 0.21^a

−0.057 ± 0.21^a

17.49 ± 9.49

15.95 ± 9.40

47.00 ± 17.51

37.19 ± 13.23