Parkinson disease polygenic risk score is associated with Parkinson disease status and age at onset but not with alpha-synuclein cerebrospinal fluid levels

Table 3 Association between Genetic Risk Score and PD Status, age at onset and CSF Biomarker Levels

Trait^a	Combined			PPMI			WUSTL
Trait^a	P.Value	Beta^b	95% CI	P.Value	Beta^b	95% CI	P.Value	Beta^b	95% CI
PD Status	5.83 × 10 ⁻⁰⁸	5.24	3.35–7.12	3.45 × 10 ⁻⁰⁵	5.84	3.10–8.59	1.82 × 10 ⁻⁰⁴	4.85	2.32–7.39
Age at Onset (Survival)	5.70 × 10 ⁻⁰⁷	11.20	6.81–15.58	3.19 × 10 ⁻⁰⁶	16.62	9.63–23.61	1.41 × 10 ⁻⁰³	9.30	3.59–15.00
CSF α-Syn Levels	0.21	−0.57	−1.47 – 0.33	0.66	−0.24	−1.30 – 0.82	0.06	−1.60	−3.28 – 0.07
CSF Aβ_1–42 Levels	0.06	−0.63	−1.29 – 0.03	0.27	−0.44	−1.21 - -0.33	0.07	−1.19	−2.50 – 0.11
CSF Tau Levels	0.02	−1.01	−1.87 - -0.16	0.06	−0.95	−1.94 – 0.04	0.17	−1.20	−2.95 – 0.54
CSF P-Tau Levels	0.15	−0.87	−2.07 – 0.33	0.21	−0.87	−2.23 – 0.50	0.31	−1.13	−3.33 – 1.06

^aStatistical model for each trait: PD-Status ~ PRS + age at last assessment + sex + PC1 + PC2; Age at Onset ~ PRS + sex + PC1 + PC2 (Cox Regression); α-synuclein levels ~ PRS + age at LP + sex + PC1 + PC2; Aβ_1–42 levels ~ PRS + age at LP + sex + PC1 + PC2; Tau levels ~ PRS + age at LP + sex + PC1 + PC2; P-Tau levels ~ PRS + age at LP + sex + PC1 + PC2
^bBeta per PRS unit In bold are the statistically significant p values

ISSN: 1471-2377