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Table 4 The differences between any two of the four datasets calculated by the P value of Mann-Whitney U test or Chi-squared test

From: Revealing Alzheimer’s disease genes spectrum in the whole-genome by machine learning

Features

 

AD-associated dataset

Control dataset

AD-predicted dataset

Non-mental-health dataset

Gene length

(Mann-Whitney U test)

AD- associated set

< 2.2E-16

0.01607

0.002573

Control dataset

< 2.2E-16

< 2.2E-16

< 2.2E-16

AD-predicted dataset

0.01607

< 2.2E-16

0.2018

Non-mental-health dataset

0.002573

< 2.2E-16

0.2018

Length of 3’ UTR

(Mann-Whitney U test)

AD-associated set

< 2.2E-16

0.109

0.1131

Control dataset

< 2.2E-16

< 2.2E-16

< 2.2E-16

AD-predicted dataset

0.109

< 2.2E-16

0.0003546

Non-mental-health dataset

0.1131

< 2.2E-16

0.0003546

Length of 5’ UTR

(Mann-Whitney U test)

AD-associated dataset

1.17E-13

0.4351

0.008426

Control dataset

1.17E-13

< 2.2E-16

3.05E-13

AD-predicted dataset

0.4351

< 2.2E-16

0.000159

Non-mental-health dataset

0.008426

3.05E-13

0.000159

Transcript count

(Mann-Whitney U test)

AD-associated dataset

< 2.2E-16

0.2962

0.0006213

Control dataset

< 2.2E-16

< 2.2E-16

< 2.2E-16

AD-predicted dataset

0.2962

< 2.2E-16

0.0006213

Non-mental-health dataset

0.0006213

< 2.2E-16

0.0006213

Number of exon

(Mann-Whitney U test)

AD-associated dataset

< 2.2E-16

0.1314

0.3506

Control dataset

< 2.2E-16

< 2.2E-16

< 2.2E-16

AD-predicted dataset

0.1314

< 2.2E-16

0.1537

Non-mental-health dataset

0.3506

< 2.2E-16

0.1537

Transmembrane domain

(Chi-square test)

AD- associated set

0.03783

0.8109

0.6143

Control dataset

0.03783

0.01107

0.0448

AD-predicted dataset

0.8109

0.01107

0.302

Non-mental-health dataset

0.6143

0.0448

0.302

Signal domain

(Chi-square test)

AD- associated set

3.70E-07

0.89

3.54E-05

Control dataset

3.70E-07

1.20E-08

0.006176

AD-predicted dataset

0.89

1.20E-08

1.12E-08

Non-mental-health dataset

3.54E-05

0.006176

1.12E-08

Paralog

(Chi-square test)

AD- associated set

< 2.2E-16

0.05604

0.0007944

Control dataset

< 2.2E-16

< 2.2E-16

< 2.2E-16

AD-predicted dataset

0.05604

< 2.2E-16

5.19E-13

Non-mental-health dataset

0.0007944

< 2.2E-16

5.19E-13