Skip to main content

Table 2 Relationship between mean dosage of CBZ per body weight, mean plasma CBZ concentrations and ALT/AST levels

From: Glutathione S-transferase M1 and T1 polymorphisms and the risk of mild hepatotoxicity induced by carbamazepine in a tunisian population study

  ALT p-value OR* (95% CI) AST p-value OR* (95% CI)
  Normal
(n) 83
Elevated
(n) 46
   Normal
(n) 96
Elevated
(n) 33
  
Mean dosage (mg/kg/day) 7.92 ± 3.80 7.96 ± 2.06 0.94 1.004 (0.89–1.12) 7.96 ± 3.57 7.88 ± 2.26 0.91 0.99 (0.88–1.12)
Mean plasma carbamazepine concentrations (μg/mL) 6.25 ± 2.70 6.65 ± 2.38 0.40 1.062 (0.92–1.22) 6.18 ± 2.77 7.01 ± 1.88 0.11 1.14 (0.97–1.33)
  1. H0: no difference between mean dosage of CBZ per body weight, mean plasma CBZ concentrations and ALT/AST levels
  2. p<0.05 is significant