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Table 2 Relationship between mean dosage of CBZ per body weight, mean plasma CBZ concentrations and ALT/AST levels

From: Glutathione S-transferase M1 and T1 polymorphisms and the risk of mild hepatotoxicity induced by carbamazepine in a tunisian population study

 

ALT

p-value

OR* (95% CI)

AST

p-value

OR* (95% CI)

 

Normal

(n) 83

Elevated

(n) 46

  

Normal

(n) 96

Elevated

(n) 33

  

Mean dosage (mg/kg/day)

7.92 ± 3.80

7.96 ± 2.06

0.94

1.004 (0.89–1.12)

7.96 ± 3.57

7.88 ± 2.26

0.91

0.99 (0.88–1.12)

Mean plasma carbamazepine concentrations (μg/mL)

6.25 ± 2.70

6.65 ± 2.38

0.40

1.062 (0.92–1.22)

6.18 ± 2.77

7.01 ± 1.88

0.11

1.14 (0.97–1.33)

  1. H0: no difference between mean dosage of CBZ per body weight, mean plasma CBZ concentrations and ALT/AST levels
  2. p<0.05 is significant
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BMC Neurology

ISSN: 1471-2377

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