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Table 3 Mean values of ALT and AST in each genotype

From: Glutathione S-transferase M1 and T1 polymorphisms and the risk of mild hepatotoxicity induced by carbamazepine in a tunisian population study

  ALT (IU/l) p-value* AST (IU/l) p-value*
GSTM1 genotype (n)
 Null (96) 37.5 ± 5,716 10 −3 35.03 ± 11,8 0.004
 Present (33) 30.93 ± 6,025 28.81 ± 4,35
GSTT1 genotype (n)
 Null (23) 34.47 ± 8,36 0.27 35.26 ± 8,20 0.37
 Present (106) 36.11 ± 5,96 33.05 ± 11,21
Combination of GSTM1/GSTT1 (n)
 M1+/T1+ (19) 32.74 ± 6,87   28.42 ± 5,57  
 M1+/T1- (8) 33.87 ± 10,66   53.62 ± 23,91 10 -3a
 M1−/T1+ (66) 35.86 ± 3,88 0.02 a 29.31 ± 4,57  
 M1−/T1- (35) 37.88 ± 8,28 0.03 a 39.71 ± 8,47 10 -3a
  1. Null hypothese H0: no differences between the mean values of ALT and AST in each GSTM1(−) and GSTT1(−), combined GSTM1(−) and GSTT(−) and mean values of ALT and AST
  2. p-value* by Mann-Whitney U test
  3. aCompared with M1+/T1+
  4. Bold entries indicate significance