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Table 3 Mean values of ALT and AST in each genotype

From: Glutathione S-transferase M1 and T1 polymorphisms and the risk of mild hepatotoxicity induced by carbamazepine in a tunisian population study

 

ALT (IU/l)

p-value*

AST (IU/l)

p-value*

GSTM1 genotype (n)

 Null (96)

37.5 ± 5,716

10 −3

35.03 ± 11,8

0.004

 Present (33)

30.93 ± 6,025

28.81 ± 4,35

GSTT1 genotype (n)

 Null (23)

34.47 ± 8,36

0.27

35.26 ± 8,20

0.37

 Present (106)

36.11 ± 5,96

33.05 ± 11,21

Combination of GSTM1/GSTT1 (n)

 M1+/T1+ (19)

32.74 ± 6,87

 

28.42 ± 5,57

 

 M1+/T1- (8)

33.87 ± 10,66

 

53.62 ± 23,91

10 -3a

 M1−/T1+ (66)

35.86 ± 3,88

0.02 a

29.31 ± 4,57

 

 M1−/T1- (35)

37.88 ± 8,28

0.03 a

39.71 ± 8,47

10 -3a

  1. Null hypothese H0: no differences between the mean values of ALT and AST in each GSTM1(−) and GSTT1(−), combined GSTM1(−) and GSTT(−) and mean values of ALT and AST
  2. p-value* by Mann-Whitney U test
  3. aCompared with M1+/T1+
  4. Bold entries indicate significance
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BMC Neurology

ISSN: 1471-2377

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