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Table 4 Distribution of GSTM1 and GSTT1 alleles in patients with elevated or normal levels of ALT and AST

From: Glutathione S-transferase M1 and T1 polymorphisms and the risk of mild hepatotoxicity induced by carbamazepine in a tunisian population study

 

ALT

p-value

OR* (95% CI)

AST

p-value

OR* (95% CI)

 

Normal

Elevated

  

Normal

Elevated

  

GSTM1 genotype (n)

 Null

54

42

0.0022

5.64 (1.70–20.60)

64

32

0.0013

11 (1.56–77.37)

 Present

29

4

32

1

GSTT1 genotype (n)

 Null

15

8

0.88

0.95 (0.33–2.68)

15

8

0.39

1.73 (0.59–5.01)

 Present

68

38

81

25

Combination of GSTM1/GSTT1

 M1+/T1+

15

4

 

1.0

17

2

 

1.0

 M1+/T1-

5

3

0.68

0.44 (0.05–3.74)

0

8

0.99

4(Undefined)

 M1−/T1+

48

18

0.80

0.71 (0.17–2.73)

64

2

0.45

3.76 (0.34–41.37)

 M1−/T1-

14

21

0.014

0.18 (0.04–0.75)

14

21

0.0012

0.08 (0.01–0.45)

  1. Null hypothese (H0): no differences between GSTM1 and GSTT1 alleles in patients with elevated or normal levels of ALT and AST
  2. p<0.05 is significant
  3. Bold entries indicate significance