Skip to main content

Table 4 Distribution of GSTM1 and GSTT1 alleles in patients with elevated or normal levels of ALT and AST

From: Glutathione S-transferase M1 and T1 polymorphisms and the risk of mild hepatotoxicity induced by carbamazepine in a tunisian population study

  ALT p-value OR* (95% CI) AST p-value OR* (95% CI)
  Normal Elevated    Normal Elevated   
GSTM1 genotype (n)
 Null 54 42 0.0022 5.64 (1.70–20.60) 64 32 0.0013 11 (1.56–77.37)
 Present 29 4 32 1
GSTT1 genotype (n)
 Null 15 8 0.88 0.95 (0.33–2.68) 15 8 0.39 1.73 (0.59–5.01)
 Present 68 38 81 25
Combination of GSTM1/GSTT1
 M1+/T1+ 15 4   1.0 17 2   1.0
 M1+/T1- 5 3 0.68 0.44 (0.05–3.74) 0 8 0.99 4(Undefined)
 M1−/T1+ 48 18 0.80 0.71 (0.17–2.73) 64 2 0.45 3.76 (0.34–41.37)
 M1−/T1- 14 21 0.014 0.18 (0.04–0.75) 14 21 0.0012 0.08 (0.01–0.45)
  1. Null hypothese (H0): no differences between GSTM1 and GSTT1 alleles in patients with elevated or normal levels of ALT and AST
  2. p<0.05 is significant
  3. Bold entries indicate significance