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Rationale and design of the CAROLINA® - cognition substudy: a randomised controlled trial on cognitive outcomes of linagliptin versus glimepiride in patients with type 2 diabetes mellitus

  • Geert Jan Biessels1Email authorView ORCID ID profile,
  • Jolien Janssen1, 2,
  • Esther van den Berg1, 3,
  • Bernard Zinman4,
  • Mark A. Espeland5,
  • Michaela Mattheus6,
  • Odd Erik Johansen7 and
  • on behalf of the CAROLINA® investigators
BMC NeurologyBMC series – open, inclusive and trusted201818:7

https://doi.org/10.1186/s12883-018-1014-7

Received: 10 May 2017

Accepted: 3 January 2018

Published: 15 January 2018

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Open Peer Review reports

Pre-publication versions of this article are available by contacting info@biomedcentral.com.

Original Submission
10 May 2017 Submitted Original manuscript
16 May 2017 Reviewed Reviewer Report - Naomi Chaytor
5 Jul 2017 Reviewed Reviewer Report - Michael Donohue
14 Jul 2017 Author responded Author comments - Geert Jan Biessels
Resubmission - Version 2
14 Jul 2017 Submitted Manuscript version 2
16 Aug 2017 Reviewed Reviewer Report - Michael Donohue
17 Nov 2017 Author responded Author comments - Geert Jan Biessels
Resubmission - Version 3
17 Nov 2017 Submitted Manuscript version 3
Publishing
3 Jan 2018 Editorially accepted
15 Jan 2018 Article published 10.1186/s12883-018-1014-7

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article are available by contacting info@biomedcentral.com.

You can find further information about the peer review system here.

Authors’ Affiliations

(1)
Department of Neurology, G03.232 Brain Center Rudolf Magnus, University Medical Center, Utrecht, the Netherlands
(2)
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands
(3)
Department of Neurology, Erasmus MC - University Medical Center, Rotterdam, the Netherlands
(4)
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada, Division of Endocrinology, University of Toronto, Toronto, Canada
(5)
Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, USA
(6)
Global biometrics and datamanagement, Boehringer Ingelheim, Ingelheim, Germany
(7)
Clinical development, Therapeutic Area Metabolism, Boehringer Ingelheim, Asker, Norway

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