Table 1 Demographic variables and clinical symptoms of PDSN+ and PDSN- groups
Demographic features | PDSN- group | PDSN+ group | P value |
|---|---|---|---|
Gender | 0.028* | ||
Male [case (%)] | 15(48.4%) | 64(70.3%) | |
Female [case (%)] | 16(51.6%) | 27(29.7%) | |
Age (year, mean ± SD) | 54.3 ± 11.1 | 62.0 ± 9.6 | 0.002** |
Age of onset (year, mean ± SD) | 51.1 ± 10.9 | 57.9 ± 11.0 | 0.006** |
Disease duration [year, median (quartile)] | 2.0(1.0~ 4.0) | 2.0(1.0~ 5.0) | 0.919 |
MS | |||
H-Y stage [stage, median (quartile)] | 2.0(1.0~ 5.0) | 4.0(2.0~ 8.0) | 0.004** |
UPDRS III total score [score, median (quartile)] | 21.6 ± 11.8 | 24.1 ± 13.6 | 0.467 |
MNS | |||
Cognitive impairment | |||
MoCA (score, mean ± SD) | 22.7 ± 5.8 | 20.1 ± 5.4 | 0.047* |
Visuospatial and execution[score, median(quartile)] | 3.0(2.0~ 5.0) | 3.0(2.0~ 4.0) | 0.992 |
Naming [score, median (quartile)] | 3.0(3.0~ 3.0) | 3.0(2.0~ 3.0) | 0.045* |
Memory [score, median (quartile)] | 3.0(0~ 4.0) | 3.0(0~ 3.0) | 0.038* |
Attention and calculation [score, median (quartile)] | 6.0(4.5~ 6.0) | 6.0(4.0~ 6.0) | 0.067 |
Language [score, median (quartile)] | 2.0(2.0~ 3.0) | 2.0(2.0~ 3.0) | 0.953 |
Abstraction [score, median (quartile)] | 1.0(1.0~ 2.0) | 1.0(1.0~ 2.0) | 0.408 |
Orientation [score, median (quartile)] | 6.0(6.0~ 6.0) | 6.0(5.0~ 6.0) | 0.709 |
Autonomic symptoms | |||
Digestive function [score, median (quartile)] | 8.0(7.0~ 10.0) | 10.0(9.0~ 11.0) | 0.001** |
Urination function [score, median (quartile)] | 7.0(6.0~ 9.0) | 10.0(8.0~ 13.0) | 0.000** |
Cardiovascular function [score, median(quartile)] | 3.5(3.0~ 4.0) | 4.0(3.0~ 6.0) | 0.067 |
Temperature regulation (score, mean ± SD) | 5.7 ± 1.8 | 6.5 ± 2.2 | 0.116 |
Pupil adjustment [score, median(quartile)] | 1.0(1.0~ 2.0) | 1.0(1.0~ 2.0) | 0.047* |
Sexual function (score, mean ± SD) | 3.0 ± 1.5 | 4.0 ± 2.0 | 0.175 |
SCOPA-AUT total score (score, mean ± SD) | 33.5 ± 7.7 | 36.8 ± 9.0 | 0.044* |
Emotional disorders | |||
HAMD [score, median (quartile)] | 10.0(3.0~ 16.0) | 10.0(5.0~ 17.0) | 0.538 |
HAMA [score, median (quartile)] | 8.0(4.0~ 18.0) | 11.0(5.0~ 17.0) | 0.623 |
Sleep disorder | |||
PSQI [score, median (quartile)] | 6.0(2.0~ 12.0) | 5.0(2.0~ 7.0) | 0.446 |
ESS [score, median (quartile)] | 6.0(3.0~ 9.0) | 4.0(2.0~ 8.0) | 0.829 |
Fatigue | |||
FS-14 (score, mean ± SD) | 8.6 ± 4.4 | 8.2 ± 3.8 | 0.565 |
FSS (score, mean ± SD) | 36.2 ± 15.7 | 39.6 ± 16.5 | 0.307 |
Restless leg syndrome | 0.494 | ||
No [case(%)] | 20(64.5%) | 64(70.3%) | |
Yes [case(%)] | 11(35.5%) | 27(29.7%) |