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Table 2 Frequencies of positive antibody indexes (AIs) for MRZ

From: The MRZ reaction helps to distinguish rheumatologic disorders with central nervous involvement from multiple sclerosis

Study group

RDwCNS(n = 23)

MS(n = 46)

OIND (n = 48)

Comparison statistics

Patients with 0 positive AI

87.0%

17.4%

77.1%

RDwCNS vs. OIND: n.s.

Both groups vs. MS: p < 0.0001.

Patients with 1 positive AI

4.3%

19.6%

14.6%

All comparisons: n.s.

Patients with 2 positive AIs

8.7%

28.3%

6.3%

Both groups vs. RDwCNS: n.s.

OIND vs. MS: p < 0.01

Patients with 3 positive AIs

0%

34.8%

2.1%

RDwCNS vs. OIND: n.s.

Both groups vs. MS: p < 0.001.

Positive AIs for M

8.7%

63.0%

6.3%

RDwCNS vs. OIND: n.s.

Both groups vs. MS: p < 0.0001.

Positive AIs for R

4.3%

63.0%

12.5%

RDwCNS vs. OIND: n.s.

Both groups vs. MS: p < 0.0001.

Positive AIs for Z

8.7%

54.3%

14.6%

RDwCNS vs. OIND: n.s.

Both groups vs. MS: p < 0.0001.

Mean AI values for M (range; SD)

1.1

(0.6–2.0; 0.3)

4.0

(0.6–52.2; 7.6)

1.0

(0.6–2.6; 0.3)

RDwCNS vs. OIND: n.s.

Both groups vs. MS: p < 0.0001.

Mean AI values for R (range; SD)

1.1

(0.6–3.6; 0.6)

3.4

(0.7–19.8; 4.2)

1.2

(0.6–8.3; 1.2)

RDwCNS vs. OIND: n.s.

Both groups vs. MS: p < 0.0001.

Mean AI values for Z (range; SD)

1.2

(0.6–4.2; 0.7)

3.9

(0.6–25.4; 5.2)

1.2

(0.4–3.8; 0.6)

RDwCNS vs. OIND: n.s.

Both groups vs. MS: p < 0.01.

  1. RDwCNS Rheumatologic disorders with CNS involvement, MS Multiple sclerosis, OIND Other inflammatory autoimmune neurological diseases [17], SD Standard deviation; positive AI Antibody index for measles (M), rubella (R) or varicella zoster (Z) ≥ 1.5; n.s Not significant