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Table 2 Frequencies of positive antibody indexes (AIs) for MRZ

From: The MRZ reaction helps to distinguish rheumatologic disorders with central nervous involvement from multiple sclerosis

Study group RDwCNS(n = 23) MS(n = 46) OIND (n = 48) Comparison statistics
Patients with 0 positive AI 87.0% 17.4% 77.1% RDwCNS vs. OIND: n.s.
Both groups vs. MS: p < 0.0001.
Patients with 1 positive AI 4.3% 19.6% 14.6% All comparisons: n.s.
Patients with 2 positive AIs 8.7% 28.3% 6.3% Both groups vs. RDwCNS: n.s.
OIND vs. MS: p < 0.01
Patients with 3 positive AIs 0% 34.8% 2.1% RDwCNS vs. OIND: n.s.
Both groups vs. MS: p < 0.001.
Positive AIs for M 8.7% 63.0% 6.3% RDwCNS vs. OIND: n.s.
Both groups vs. MS: p < 0.0001.
Positive AIs for R 4.3% 63.0% 12.5% RDwCNS vs. OIND: n.s.
Both groups vs. MS: p < 0.0001.
Positive AIs for Z 8.7% 54.3% 14.6% RDwCNS vs. OIND: n.s.
Both groups vs. MS: p < 0.0001.
Mean AI values for M (range; SD) 1.1
(0.6–2.0; 0.3)
4.0
(0.6–52.2; 7.6)
1.0
(0.6–2.6; 0.3)
RDwCNS vs. OIND: n.s.
Both groups vs. MS: p < 0.0001.
Mean AI values for R (range; SD) 1.1
(0.6–3.6; 0.6)
3.4
(0.7–19.8; 4.2)
1.2
(0.6–8.3; 1.2)
RDwCNS vs. OIND: n.s.
Both groups vs. MS: p < 0.0001.
Mean AI values for Z (range; SD) 1.2
(0.6–4.2; 0.7)
3.9
(0.6–25.4; 5.2)
1.2
(0.4–3.8; 0.6)
RDwCNS vs. OIND: n.s.
Both groups vs. MS: p < 0.01.
  1. RDwCNS Rheumatologic disorders with CNS involvement, MS Multiple sclerosis, OIND Other inflammatory autoimmune neurological diseases [17], SD Standard deviation; positive AI Antibody index for measles (M), rubella (R) or varicella zoster (Z) ≥ 1.5; n.s Not significant