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Table 2 Association results for pRBD with investigated SNCA and MAPT variants

From: Risk variants of the α-synuclein locus and REM sleep behavior disorder in Parkinson’s disease: a genetic association study

dbSNP ID Locus Alleles Frequency pRBD Frequency Non-RBD SE OR p value
Norwegian discovery dataset N = 141 pRBD-PD / 184 non-RBD-PD
rs356165 SNCA G/A 0.42 0.42 0.163 1.07 0.76
rs3756063 SNCA C/G 0.59 0.48 0.155 1.44 0.018
rs2245801 SNCA T/C 0.11 0.14 0.261 0.79 0.36
rs2942168 MAPT T/C 0.14 0.11 0.239 1.27 0.33
PPMI replication dataset: N = 106 pRBD-PD / 276 non-RBD-PD
rs3756063 SNCA C/G 0.56 0.49 0.168 1.35 0.036a
Meta-analysis across both datasets for rs3756063: 0.114 1.40 0.0032
  1. The association between SNPs and RBD was tested in a logistic regression model, including age and gender as covariates. The first allele listed is the effect allele
  2. Abbreviations: SNP single-nucleotide polymorphism, PD Parkinson’s disease, pRBD possible REM-sleep behavior disorder, OR odds ratio, SE standard error
  3. aOne-sided p-value