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Table 1 Factors associated with hemorrhagic transformation and symptomatic intracerebral hemorrhage

From: Cerebral microbleeds shouldn’t dictate treatment of acute stroke: a retrospective cohort study evaluating risk of intracerebral hemorrhage

 

All n = 292

No HT n = 246

HT n = 46

P value

No sICH n = 286

sICH n = 6

P value

Demographics

 Age, years

63 ± 15

62 ± 15

68 ± 15

.006

63 (51–75)

61 (59–65)

.944

 Female, % (n)

52 (151)

50 (124)

59 (27)

.302

52 (148)

50 (3)

.932

 Black, % (n)

49 (142)

51 (126)

35 (16)

.041

48 (138)

67 (4)

.437

 LVD, % (n)

23 (68)

20 (50)

39 (18)

.006

23 (66)

33 (2)

.891

Clinical Scales

 Initial NIHSS

7.9 ± 5.5

7.4 ± 5.3

11 ± 5.7

< .001

2 (4–10)

11 (6–12)

.373

 Discharge NIHSS

3.7 ± 5.1

3.2 ± 4.6

5.7 ± 6.7

.016

2 (0–4)

2.5 (1–9)

.373

 Follow-up NIHSS

1.3 ± 2.6

1.2 ± 2.4

1.9 ± 3.7

.331

0 (0–2)

0 (0–2)

.994

 Discharge mRS

2.6 ± 1.6

2.5 ± 1.6

3.1 ± 1.6

.032

2 (1–4)

3 (2–5)

.363

 Follow-up mRS

1.5 ± 1.6

1.5 ± 1.5

1.8 ± 1.7

.338

1 (0–3)

2 (0–4)

.755

Imaging Parameters

 Stroke Size, mililiters

15 ± 38

11 ± 35

33 ± 46

< .001

1 (0–9)

19 (3–42)

.050

 CHS Score

2 (2–3)

2 (2–3)

3 (2–3)

.143

2 (2–3)

2.5 (2–3)

.911

 Anterior Circulation, % (n)

54 (157)

48 (117)

87 (40)

< .001

53 (151)

100 (6)

.218

Clinical Parameters

 SBP, mmHg

157 ± 30

157 ± 31

155 ± 24

.731

153 (136–172)

153 (145–189)

.437

 Glucose, mg/dL

135 ± 71

133 ± 70

150 ± 76

.136

113 (97–148)

111 (103–116)

.924

 Cr, mg/dL

1.2 ± 0.7

1.2 ± 0.7

1.1 ± 0.4

.834

1 (0.8–1.3)

1.1 (0.8–1.3)

.893

 Platelets, K/cu mm

241 ± 74

244 ± 74

220 ± 66

.039

237 (191–276)

232 (217–253)

.957

Risk Factors

 CAA, % (n)

1 (3)

1 (1)

4 (2)

.073

1 (2)

17 (1)

.064

 HTN, % (n)

79 (230)

80 (194)

78 (36)

.848

79 (225)

83 (5)

.999

 DM, % (n)

27 (77)

27 (65)

26 (12)

.938

26 (75)

33 (2)

.658

 Tobacco, % (n)

29 (85)

29 (72)

28 (13)

.893

29 (82)

50 (3)

.473

 Alcohol, % (n)

24 (70)

26 (62)

17 (8)

.498

24 (68)

33 (2)

.725

 Afib, % (n)

20 (58)

16 (40)

39 (18)

< .001

19 (55)

50 (3)

.098

 Stroke History, % (n)

22 (63)

22 (54)

20 (9)

.884

21 (61)

33 (2)

.801

 HLD, % (n)

51 (149)

51 (126)

50 (23)

.859

51 (146)

50 (3)

.999

  1. Continuous data is described as mean ± standard deviation or as median (interquartile range), as appropriate per its distribution
  2. Afib atrial fibrillation, CAA cerebral amyloid angiopathy, CHS Cardiovascular Health Study criteria, Cr creatinine, DM diabetes mellitus, HLD hyperlipidemia, HT hemorrhagic transformation, HTN hypertension, LVD large vessel disease etiology, mRS modified Rankin Score, NIHSS National Institute of Health Stroke Scale, sICH symptomatic intracerebral hemorrhage, SBP systolic blood pressure, SD standard deviation
  3. Bold data indicates statistical significant (p<.05)
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BMC Neurology

ISSN: 1471-2377

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