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Fig. 4 | BMC Neurology

Fig. 4

From: Comparison of electroencephalographic changes in response to acute electrical and thermal stimuli with the tail flick and hot plate test in rats administered with opiorphin

Fig. 4

Least square means for the time spent by rats on the hot plate before and after intravenous administration of normal saline, Opiorphin and morphine. There was a significant increase in time spent by rats after an injection of morphine, while there was a significant decrease in time spent by rats after an injection of either opiorphin or normal saline. Superscripts represent significant differences. Note 1: Mean values with an asterisk over the error bars differed significantly (p < 0.05) from their respective baseline values. Note 2: Mean values with at least one common letter over the error bars, within the each time-point, did not differ significantly (p > 0.05). Note 3: Baseline = hot plate latency before the drug administration; 1 min after drug = hot plate latency 1 min after an i.v. injection of normal saline, opiorphin or morphine; 5 mins after drug = hot plate latency 5 min after an i.v. injection of normal saline, opiorphin or morphin; 5 mins Naloxone = hot plate latency 5 min after a s.c. injection of Naloxone

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