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Fig. 5 | BMC Neurology

Fig. 5

From: Comparison of electroencephalographic changes in response to acute electrical and thermal stimuli with the tail flick and hot plate test in rats administered with opiorphin

Fig. 5

Least square means for the median frequency (F50) during thermal (TS) and electrical stimulus (ES) in rats injected with normal saline (green bars), opiorphin (red bars) and morphine (blue bars). There was a significant increase in F50 in the normal saline injected rats both during the electrical and thermal stimulus. The morphine and opiorphin effect was blocked by naloxone as there was a significant increase in F50 after administration of naloxone during the electrical stimulus. Superscripts represent significant differences. Note 1: Mean values with an asterisk over the error bars differed significantly (p < 0.05) from their respective baseline values. Note 2: Mean values with at least one common letter over the error bars, within the each time-point, did not differ significantly (p > 0.05). Note 3: Baseline = F50 before the drug administration; TS post drug = F50 after an i.v. injection of normal saline, opiorphion or morphine during thermal nociceptive stimulus; ES post drug = F50 after an i.v. injection of normal saline, opiorphin or morphine during electrical nociceptive stimulus; TS post nal = F50 after a s.c. injection of naloxone

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BMC Neurology

ISSN: 1471-2377

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