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Fig. 6 | BMC Neurology

Fig. 6

From: Comparison of electroencephalographic changes in response to acute electrical and thermal stimuli with the tail flick and hot plate test in rats administered with opiorphin

Fig. 6

Least square means for the spectral edge frequency (F95) during thermal (TS) and electrical stimulus (ES) in rats injected with normal saline (green bars), opiorphin (red bars) and morphine (blue bars). There was a significant increase in F95 in normal saline rats. There was a significant increase in F95 post naloxone injection in morphine administered rats, both during electrical and thermal stimulus. There was no such difference observed in opiorphin group rats. Superscripts represent significant differences. Note 1: Mean values with an asterisk over the error bars differed significantly (p < 0.05) from their respective baseline values. Note 2: Mean values with at least one common letter over the error bars, within the each time-point, did not differ significantly (p > 0.05). Note 3: Baseline = F95 before the drug administration; TS post drug = F95 after an i.v. injection of normal saline, opiorphion or morphine during thermal nociceptive stimulus; ES post drug = F95 after an i.v. injection of normal saline, opiorphin or morphine during electrical nociceptive stimulus; TS post nal = F95 after a s.c. injection of naloxone

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BMC Neurology

ISSN: 1471-2377

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